Molecular cloning and sequencing of the human heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase from bone marrow culture

被引：3
|
作者：
Omasa, T
Chen, YG
Mantalaris, A
Tsai, YC
Wu, JHD
机构：
[1] Univ Rochester, Dept Chem Engn, Rochester, NY 14627 USA
[2] Univ Rochester, Dept Pathol, Rochester, NY 14627 USA
来源：
DNA SEQUENCE | 2002年 / 13卷 / 03期
基金：
美国国家航空航天局; 美国国家科学基金会;
关键词：
eukaryotic initiation factor; heme-regulated inhibitor; kinase; translation control; bone marrow; heme;
D O I：
10.1080/10425170290023428
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The cDNA encoding human heme-regulated eukaryotic initiation factor-2alpha (eIF-2alpha) kinase was cloned from a human bone marrow culture. Its deduced amino acid sequence comprised of 629 amino acids with a calculated molecular weight of 71,031 Da. RT-PCR analysis revealed that the gene was also expressed in heart, kidney, spleen, muscle, and stomach.
引用
收藏
页码：133 / 137
页数：5
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