Adeno-associated virus as a gene delivery system

被引：53
|
作者：
During, MJ
机构：
[1] Department of Molecular Medicine, University of Auckland, School of Medicine, Auckland
来源：
ADVANCED DRUG DELIVERY REVIEWS | 1997年 / 27卷 / 01期
关键词：
adeno-associated virus; gene delivery; neurodegenerative disease;
D O I：
10.1016/S0169-409X(97)00024-0
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Adeno-associated virus (AAV) has several characteristics which make it extremely attractive as a gene transfer vector: (1) no known pathogenicity; (2) high efficiency and the ability to remain latent, (3) a minimal number of antigens ensuring minimal immunogenicity; (4) the ability to transduce post-mitotic cells; (5) possible advantages of site-specific integration; and (6) a broad host and cell range. The human isolate, AAV-2, is the best studied and has been the focus for gene delivery experiments. This review will discuss recent in vivo experiments demonstrating the utility of AAV in animal models of neurodegenerative disease. (C) 1997 Elsevier Science B.V.
引用
收藏
页码：83 / 94
页数：12
相关论文
共 50 条
  • [21] My Pathway to Adeno-Associated Virus and Adeno-Associated Virus Gene Therapy: A Personal Perspective
    Carter, Barrie J.
    [J]. HUMAN GENE THERAPY, 2020, 31 (9-10) : 494 - 498
  • [22] Delivery of Adeno-Associated Virus Vectors to the Central Nervous System for Correction of Single Gene Disorders
    Daci, Rrita
    Flotte, Terence R.
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (02)
  • [23] Adeno-associated virus gene transfer into renal cells: Potential for in vivo gene delivery
    Langer, JC
    Klotman, ME
    Hanss, B
    Tulchin, N
    Bruggeman, LA
    Klotman, PE
    Lipkowitz, MS
    [J]. EXPERIMENTAL NEPHROLOGY, 1998, 6 (03): : 189 - 194
  • [24] Efficient Antibody Gene Delivery to CNS by Adeno-Associated Virus Vectors in Mouse
    Zhao, Huiren
    Bradley, Jodi D.
    Meisen, W. Hans
    Lin, Yun
    Rao, Sara
    Zhang, Maosheng
    Wen, Paul
    Lu, Jiamiao
    Wang, Songli
    Lee, Ki Jeong
    [J]. MOLECULAR THERAPY, 2022, 30 (04) : 487 - 487
  • [25] The next step in gene delivery: Molecular engineering of adeno-associated virus serotypes
    Wang, Jinhui
    Faust, Susan M.
    Rabinowitz, Joseph E.
    [J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2011, 50 (05) : 793 - 802
  • [26] Intraparenchymal delivery of adeno-associated virus vectors for the gene therapy of neurological diseases
    Kumagai, Shinichi
    Nakajima, Takeshi
    Muramatsu, Shin-ichi
    [J]. EXPERT OPINION ON BIOLOGICAL THERAPY, 2024, 24 (08) : 773 - 785
  • [27] Directed evolution of adeno-associated virus yields enhanced gene delivery vectors
    Maheshri, N
    Koerber, JT
    Kaspar, BK
    Schaffer, DV
    [J]. NATURE BIOTECHNOLOGY, 2006, 24 (02) : 198 - 204
  • [28] Gene delivery via the hybrid vector of recombinant adeno-associated virus and polyethylenimine
    Hsu, Paul Y. -J.
    Yang, Ya-Wun
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2014, 52 : 62 - 68
  • [29] Creating an arsenal of Adeno-associated virus (AAV) gene delivery stealth vehicles
    Smith, J. Kennon
    Agbandje-McKenna, Mavis
    [J]. PLOS PATHOGENS, 2018, 14 (05)
  • [30] Comparison of Adeno-Associated Virus Serotypes and Delivery Methods for Cardiac Gene Transfer
    Fang, Hongfei
    Lai, Ngai Chin
    Gao, Mei Hua
    Miyanohara, Atsushi
    Roth, David M.
    Tang, Tong
    Hammond, H. Kirk
    [J]. HUMAN GENE THERAPY METHODS, 2012, 23 (04) : 234 - 241
12345