Adeno-associated virus as a gene delivery system

被引：53
|
作者：
During, MJ
机构：
[1] Department of Molecular Medicine, University of Auckland, School of Medicine, Auckland
来源：
ADVANCED DRUG DELIVERY REVIEWS | 1997年 / 27卷 / 01期
关键词：
adeno-associated virus; gene delivery; neurodegenerative disease;
D O I：
10.1016/S0169-409X(97)00024-0
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Adeno-associated virus (AAV) has several characteristics which make it extremely attractive as a gene transfer vector: (1) no known pathogenicity; (2) high efficiency and the ability to remain latent, (3) a minimal number of antigens ensuring minimal immunogenicity; (4) the ability to transduce post-mitotic cells; (5) possible advantages of site-specific integration; and (6) a broad host and cell range. The human isolate, AAV-2, is the best studied and has been the focus for gene delivery experiments. This review will discuss recent in vivo experiments demonstrating the utility of AAV in animal models of neurodegenerative disease. (C) 1997 Elsevier Science B.V.
引用
收藏
页码：83 / 94
页数：12
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