Structural studies of immunomodulatory (1 → 3)-, (1 → 4)-α glucan from an edible mushroom Polyporus grammocephalus

被引：15
|
作者：
Patra, Sukesh [1 ]
Maity, Prasenjit [2 ]
Chakraborty, Indranil [3 ]
Sen, Ipsita Kumar [4 ]
Ghosh, Debosree [5 ]
Rout, Dilip [6 ]
Bhanja, Sunil Kumar [7 ]
机构：
[1] Midnapore Coll Autonomous, Dept Chem, Paschim Medinipur 721101, W Bengal, India
[2] Sabang Sajanikanta Mahavidyalaya, Dept Chem, Paschim Medinipur 721166, W Bengal, India
[3] Kharagpur Coll, Dept Chem, Paschim Medinipur 721305, W Bengal, India
[4] Govt Gen Degree Coll, Dept Chem, Paschim Medinipur 721516, W Bengal, India
[5] Govt Gen Degree Coll, Dept Physiol, Kharagpur 2, Paschim Medinipur 721149, W Bengal, India
[6] Jhargram Raj Coll, Dept Chem, Jhargram 721507, W Bengal, India
[7] Govt Gen Degree Coll, Dept Chem, Kharagpur 2, Paschim Medinipur 721149, W Bengal, India
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2021年 / 168卷
关键词：
Polyporus grammocephalus; NMR studies; Immunostimulation; WATER-SOLUBLE POLYSACCHARIDES; ANTITUMOR POLYSACCHARIDES; IMMUNOENHANCING GLUCAN; FRUITING BODY; BETA-GLUCAN; ELUCIDATION; ANTIOXIDANT; EXTRACT; FUNGI; HETEROGLYCAN;
D O I：
10.1016/j.ijbiomac.2020.11.121
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A water soluble polysaccharide (PGPS) with molecular weight similar to 1.4 x 10(5) Da was isolated by alkali treatment from an edible mushroom Polyporus grammocephalus and purified by gel chromatography using sepharose-6B column. Monosaccharide analysis revealed that PGPS was made up of glucose only. PGPS contained (1 -> 3)-alpha-D-Glcp and (1 -> 4)-alpha-D-Glcp moieties in a molar ratio of nearly 1:2. Through a series of chemical and spectroscopic (1D/2D NMR) investigations, the repeating unit of the glucan was established as: -> 3)-alpha-D-Glcp(1 -> [4)-alpha-D-Glcp(1]2 -> This alpha-glucan was observed to stimulate some prime components of immune system, namely, macrophages, splenocytes, and thymocytes. (C) 2020 Elsevier B.V. All rights reserved.
引用
收藏
页码：649 / 655
页数：7
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