Synthesis and antibacterial activity of novel coumarin-chalcone hybrids

Naturally and synthetically derived hybrid molecules are an attractive basis for therapeutic agent development due to their dual or multiple modes of action and other advantages. We have synthesized coumarin-chalcone hybrids with the aim of evaluating their antimicrobial properties. The structural variations have been selected by introducing various amines at chloro acetyl group as well as various isothiocyanate and isocyanate at amine group. The structures of all the newly synthesised compounds have been confirmed by their FTIR, H-1 and C-13 NMR, mass spectral as well as elemental analysis data. All the newly synthesized compounds have been screened for non automated in vitro antimicrobial and antimycobacterial activity against selected pathogens. Some of the newly synthesized compounds exhibit excellent antimicrobial activity and said to be the most proficient members of the series compared to standard drugs and for future scope. The synthesized compounds are expected to assist medicinal chemists in useful and successful development of coumarin-chalcone hybrids.