Unexpected and Green Synthesis of Azapodophyllotoxin Derivatives via Microwave-Assisted Multicomponent Reactions in Ammonia Water

被引：11
|
作者：
Shi, Feng [1 ]
Ma, Ning [1 ]
Zhang, Yan [2 ]
Zhang, Ge [1 ]
Jiang, Bo [1 ]
Tu, Shujiang [1 ]
机构：
[1] Xuzhou Normal Univ, Sch Chem & Chem Engn, Key Lab Biotechnol Med Plant, Xuzhou, Jiangsu, Peoples R China
[2] Nanjing Univ, Coll Chem & Chem Engn, Nanjing 210008, Jiangsu, Peoples R China
来源：
SYNTHETIC COMMUNICATIONS | 2010年 / 40卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Azapodophyllotoxin; green synthesis; microwave irradiation; water; ORGANIC-REACTIONS; PODOPHYLLOTOXIN; IRRADIATION; ANALOGS; EFFICIENT; SOLVENT; DISCOVERY; POTENT;
D O I：
10.1080/00397910902964825
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An unexpected and green synthesis of azapodophyllotoxin derivatives was realized via microwave-assisted multicomponent reactions of dimedone, tetronic acid, and aromatic aldehydes in ammonia water. This protocol has the advantages of environmental friendliness, short reaction time, good yields, low cost, and easy operation.
引用
收藏
页码：235 / 241
页数：7
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