Evolution of Carbapenem-Resistant Serotype K1 Hypervirulent Klebsiella pneumoniae by Acquisition of blaVIM-1-Bearing Plasmid

被引：25
|
作者：
Dong, Ning [1 ,2 ]
Sun, Qiaoling [3 ]
Huang, Yonglu [3 ]
Shu, Lingbin [3 ]
Ye, Lianwei [1 ,2 ]
Zhang, Rong [3 ]
Chen, Sheng [1 ,2 ]
机构：
[1] Hong Kong PolyU Shen Zhen Res Inst, Food Safety & Technol Res Ctr, Shenzhen Key Lab Food Biol Safety Control, Shenzhen, Peoples R China
[2] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, State Key Lab Chirosci, Hung Hom,Kowloon, Hong Kong, Peoples R China
[3] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Clin Lab, Hangzhou, Zhejiang, Peoples R China
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2019年 / 63卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Klebsiella pneumoniae; VIM; carbapenem resistance; hypervirulence;
D O I：
10.1128/AAC.01056-19
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We report the identification of a carbapenem-resistant, hypervirulent Klebsiella pneumoniae (hvKp) strain which produced the carbapenemase VIM-1. Genomic analysis showed that the strain belonged to sequence type ST23 and serotype K1, a major hvKp clone, and harbored three resistance-encoding plasmids. Among them, a bla(VIM-1)-bearing plasmid was found to possess a mosaic structure presumably generated by multiple gene mobilization events. This finding indicates that hvKp actively acquires mobile resistance-encoding elements, facilitating simultaneous expression of hypervirulence and carbapenem-resistance.
引用
收藏
页数：5
相关论文
共 50 条
  • [31] Multiple organ failure by serotype K1 Klebsiella pneumoniae
    Barbeito-Castineiras, Gema
    Ladra Gonzalez, Maria Jesus
    Dominguez Santalla, Maria Jesus
    Rivero Velasco, Carmen
    ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA, 2017, 35 (05): : 321 - 322
  • [32] Carbapenem-resistant hypervirulent ST23 Klebsiella pneumoniae with a highly transmissible dual-carbapenemase plasmid in Chile
    Galvez-Silva, Matias
    Arros, Patricio
    Berrios-Pasten, Camilo
    Villamil, Aura
    Rodas, Paula I.
    Araya, Ingrid
    Iglesias, Rodrigo
    Araya, Pamela
    Hormazabal, Juan C.
    Bohle, Constanza
    Chen, Yahua
    Gan, Yunn-Hwen
    Chavez, Francisco P.
    Lagos, Rosalba
    Marcoleta, Andres E.
    BIOLOGICAL RESEARCH, 2024, 57 (01)
  • [33] Global emergence of Carbapenem-resistant Hypervirulent Klebsiella pneumoniae driven by an IncFIIK34 KPC-2 plasmid
    Jiang, Jianping
    Wang, Leilei
    Hu, Yiyi
    Chen, Xin
    Li, Pei
    Zhang, Jianfeng
    Zhang, Yixin
    Su, Jiachun
    Xu, Xiaogang
    Xiao, Yonghong
    Liu, Zhengyin
    Yu, Yunsong
    Gao, Hainv
    Doi, Yohei
    van Duin, David
    Fowler, Vance G.
    Chen, Liang
    Wang, Minggui
    EBIOMEDICINE, 2025, 113
  • [34] Rapid Whole Genome Sequencing of Serotype K1 Hypervirulent Klebsiella pneumoniae from an Undocumented Chinese Migrant
    Macleod, C. K.
    Khokhar, F. A.
    Warne, B.
    Wick, R.
    Butcher, R.
    Cassimon, B.
    Hayden, P.
    Holt, K.
    Torok, M. E.
    CASE REPORTS IN INFECTIOUS DISEASES, 2021, 2021
  • [35] Carbapenem-resistant hypervirulent ST23 Klebsiella pneumoniae with a highly transmissible dual-carbapenemase plasmid in Chile
    Matías Gálvez-Silva
    Patricio Arros
    Camilo Berríos-Pastén
    Aura Villamil
    Paula I. Rodas
    Ingrid Araya
    Rodrigo Iglesias
    Pamela Araya
    Juan C. Hormazábal
    Constanza Bohle
    Yahua Chen
    Yunn-Hwen Gan
    Francisco P. Chávez
    Rosalba Lagos
    Andrés E. Marcoleta
    Biological Research, 57
  • [36] Infection with Carbapenem-resistant Hypervirulent Klebsiella Pneumoniae: clinical, virulence and molecular epidemiological characteristics
    Li, Linlin
    Li, Shan
    Wei, Xianzhen
    Lu, Zhaolu
    Qin, Xue
    Li, Meng
    ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL, 2023, 12 (01)
  • [37] One-year surveillance for hypervirulent Klebsiella pneumoniae detected carbapenem-resistant superbugs
    Merla, C.
    Kuka, A.
    Mileto, I.
    Petazzoni, G.
    Gaiarsa, S.
    De Vitis, D.
    Ardizzone, M.
    Corbella, M.
    Baldanti, F.
    Cambieri, P.
    Doucet-Populaire, Florence Claude
    MICROBIOLOGY SPECTRUM, 2024, 12 (03):
  • [38] A nosocomial outbreak of colistin and carbapenem-resistant hypervirulent Klebsiella pneumoniae in a large teaching hospital
    Jian, Zijuan
    Liu, Yanjun
    Wang, Zhiqian
    Zeng, Lanman
    Yan, Qun
    Liu, Wenen
    SCIENTIFIC REPORTS, 2024, 14 (01):
  • [39] Emergence of a hypervirulent carbapenem-resistant Klebsiella pneumoniae isolate from clinical infections in China
    Zhang, Yawei
    Zeng, Ji
    Liu, Wenen
    Zhao, Feng
    Hu, Zhidong
    Zhao, Chunjiang
    Wang, Qi
    Wang, Xiaojuan
    Chen, Hongbin
    Li, Henan
    Zhang, Feifei
    Li, Shuguang
    Cao, Bin
    Wang, Hui
    JOURNAL OF INFECTION, 2015, 71 (05) : 553 - 560
  • [40] Infection with Carbapenem-resistant Hypervirulent Klebsiella Pneumoniae: clinical, virulence and molecular epidemiological characteristics
    Linlin Li
    Shan Li
    Xianzhen Wei
    Zhaolu Lu
    Xue Qin
    Meng Li
    Antimicrobial Resistance & Infection Control, 12
12345