Evolution of Carbapenem-Resistant Serotype K1 Hypervirulent Klebsiella pneumoniae by Acquisition of blaVIM-1-Bearing Plasmid

被引：25
|
作者：
Dong, Ning [1 ,2 ]
Sun, Qiaoling [3 ]
Huang, Yonglu [3 ]
Shu, Lingbin [3 ]
Ye, Lianwei [1 ,2 ]
Zhang, Rong [3 ]
Chen, Sheng [1 ,2 ]
机构：
[1] Hong Kong PolyU Shen Zhen Res Inst, Food Safety & Technol Res Ctr, Shenzhen Key Lab Food Biol Safety Control, Shenzhen, Peoples R China
[2] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, State Key Lab Chirosci, Hung Hom,Kowloon, Hong Kong, Peoples R China
[3] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Clin Lab, Hangzhou, Zhejiang, Peoples R China
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2019年 / 63卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Klebsiella pneumoniae; VIM; carbapenem resistance; hypervirulence;
D O I：
10.1128/AAC.01056-19
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We report the identification of a carbapenem-resistant, hypervirulent Klebsiella pneumoniae (hvKp) strain which produced the carbapenemase VIM-1. Genomic analysis showed that the strain belonged to sequence type ST23 and serotype K1, a major hvKp clone, and harbored three resistance-encoding plasmids. Among them, a bla(VIM-1)-bearing plasmid was found to possess a mosaic structure presumably generated by multiple gene mobilization events. This finding indicates that hvKp actively acquires mobile resistance-encoding elements, facilitating simultaneous expression of hypervirulence and carbapenem-resistance.
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页数：5
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