Safety Data from a First-in-Human Phase 1 Trial of NKG2D Chimeric Antigen Receptor-T Cells in AML/MDS and Multiple Myeloma

被引:25
|
作者
Nikiforow, Sarah [1 ,2 ]
Werner, Lillian [3 ]
Murad, Joana [4 ]
Jacobs, Matthew [5 ]
Johnston, Lauren [5 ]
Patches, Sarah [5 ]
White, Randie [5 ]
Daley, Heather [5 ]
Negre, Helene [5 ]
Reder, Jake [4 ]
Sentman, Charles [6 ]
Wade, Terri [4 ]
Schmucker, Adam [4 ]
Lehmann, Frederic Francois [7 ]
Snykers, Sarah [7 ]
Allen, Rachel [7 ]
Dipietro, Heidi [1 ]
Cummings, Kristen [1 ]
Galinsky, Ilene [1 ]
Munshi, Nikhil C. [1 ,2 ]
Schlossman, Robert L. [2 ]
Stone, Richard M. [1 ,2 ]
Neuberg, Donna S. [3 ]
Soiffer, Robert J. [1 ,2 ]
Dranoff, Glenn [1 ,2 ]
Ritz, Jerome [1 ,2 ]
Baumeister, Susanne H. C. [8 ]
机构
[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA USA
[2] Harvard Med Sch, Boston, MA USA
[3] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA USA
[4] Celdara Med LLC, Lebanon, NH USA
[5] Dana Farber Canc Inst, Boston, MA USA
[6] Geisel Sch Med, Dartmouth, NS, Canada
[7] Celyad, Celyad, SA, Australia
[8] Boston Childrens Hosp, Boston, MA USA
关键词
D O I
10.1182/blood.V128.22.4052.4052
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
4052
引用
收藏
页数:5
相关论文
共 50 条
  • [41] GPRC5D CART cells (OriCAR-017) in patients with relapsed or refractory multiple myeloma (POLARIS): a first-in-human, single-centre, single-arm, phase 1 trial
    Zhang, Mingming
    Wei, Guoqing
    Zhou, Linghui
    Zhou, Jincai
    Chen, Siye
    Zhang, Wei
    Wang, Dongrui
    Luo, Xueping
    Cui, Jiazhen
    Huang, Simao
    Fu, Shan
    Zhou, Xinkai
    Tang, Yu
    Ding, Xiaomin
    Kuang, Jiao
    He, Xiaowen Peter
    Hu, Yongxian
    Huang, He
    LANCET HAEMATOLOGY, 2023, 10 (02): : E107 - E116
  • [42] Natural Killer T Cells Expressing a GD2-CAR and IL-15 for Children with Neuroblastoma - A First-In-Human Phase 1 Trial
    Heczey, Andras
    Courtney, Amy
    Robinson, Simon
    Liu, Ka
    Ghatwai, Nisha
    Savoldo, Barbara
    Dotti, Gianpietro
    Metelitsa, Leonid
    MOLECULAR THERAPY, 2020, 28 (04) : 555 - 555
  • [43] Initial data from a phase 1, first-in-human clinical trial for T-Plex, a multiplexed, enhanced T cell receptor-engineered T cell therapy (TCR-T) for solid tumors.
    Thomas, Sajeve Samuel
    Pico, Brian
    Henick, Brian S.
    Leidner, Rom
    Samhouri, Yazan
    Isaacs, James
    Weiss, Jared
    Hurwitz, Michael E.
    Grewal, Jaspreet Singh
    Luke, Jason J.
    Chattopadhyay, Shrikanta
    Wang, Yun
    Motta, Marlyane
    Murray, Jim
    Barton, Debora
    Pinchasik, Dawn
    MacBeath, Gavin
    Moser, Justin C.
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
  • [44] Data from first-in-human study of EXS21546, an A2A receptor antagonist, now progressing into phase 1 in RCC/NSCLC
    Diaz, Nieves
    Garratt, Holly
    Zemla-Brown, Aleksandra
    Dominguez, Maria
    Helmer, Eric
    Alt, Isabella
    Sehlke, Robert
    Hieger, Norbert
    Winkler-Penz, Thomas
    Boudesco, Christophe
    Vladimer, Gregory
    Wilde, Tom
    Evans, Philip
    Italiano, Antoine
    Krams, Michael
    CANCER RESEARCH, 2023, 83 (08)
  • [45] Updated Safety and Efficacy of REGN5458, a BCMAxCD3 Bispecific Antibody, Treatment for Relapsed/Refractory Multiple Myeloma: A Phase 1/2 First-in-Human Study
    Bumma, Naresh
    Richter, Joshua
    Brayer, Jason
    Zonder, Jeffrey A.
    Dhodapkar, Madhav
    Shah, Mansi R.
    Hoffman, James E.
    Mawad, Raya
    Maly, Joseph J.
    Lentzsch, Suzanne
    Suvannasankha, Attaya
    Roy, Pourab
    Dey, Jyotirmoy
    Chokshi, Dhruti
    Boyapati, Anita
    Visich, Jenn
    Houvras, Yariv
    Lorenc, Karen Rodriguez
    Kroog, Glenn S.
    Jagannath, Sundar
    BLOOD, 2022, 140 : 10140 - 10141
  • [46] A phase 1, first-in-human study of autologous monocytes engineered to express an anti-HER2 chimeric antigen receptor (CAR) in participants with HER2-overexpressing solid tumors.
    Abdou, Yara
    Pohlmann, Paula R.
    Maziarz, Richard T.
    Murthy, Hemant S.
    Yuan, Yuan
    Krishnamurthy, Anuradha
    Reiss, Kim Anna
    Isaacs, James
    Blumenthal, Daniel
    Gabitova, Linara
    Menchel, Brett
    Locke, Kenneth
    Wetzel, Jeanette
    Klichinsky, Michael
    Cushing, Daniel
    Condamine, Thomas
    Sohal, Davendra
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
  • [47] Phase I First-in-Human Study on the Feasibility, Safety, and Antitumor Activity of CD4-Redirected Chimeric Antigen Receptor (CAR) T-Cell Therapy in Patients with CD4+T-Cell Malignancies (TCM)
    Assi, Rita
    Hagag, Nabil
    Farag, Sherif
    Emmons, Robert V. B.
    Carter, Allie
    Czader, Magdalena
    Abonour, Rafat
    Apetoh, Lionel
    Ma, Yupo
    Salman, Huda S.
    BLOOD, 2023, 142
  • [48] Deep and Durable Remissions of Relapsed Multiple Myeloma on a First-in-Humans Clinical Trial of T Cells Expressing an Anti-B-Cell Maturation Antigen (BCMA) Chimeric Antigen Receptor (CAR) with a Fully-Human Heavy-Chain-Only Antigen Recognition Domain
    Mikkilineni, Lekha
    Manasanch, Elisabet E.
    Vanasse, Danielle
    Brudno, Jennifer N.
    Mann, Jennifer
    Sherry, Richard
    Goff, Stephanie L.
    Yang, James C.
    Lam, Norris
    Maric, Irina
    Stetler-Stevenson, Maryalice
    Wang, Hao-Wei
    Yuan, Constance M.
    Stroncek, David F.
    Highfill, Steven L.
    Fellowes, Vicki
    Ganadan, Micaela
    Patel, Rashmika
    Rosenberg, Steven A.
    Kochenderfer, James N.
    BLOOD, 2020, 136
  • [49] CARTITUDE-1: Phase 1b/2 Study of Ciltacabtagene Autoleucel, a B-Cell Maturation Antigen-Directed Chimeric Antigen Receptor T Cell Therapy, in Relapsed/Refractory Multiple Myeloma
    Madduri, Deepu
    Berdeja, Jesus G.
    Usmani, Saad Z.
    Jakubowiak, Andrzej
    Agha, Mounzer
    Cohen, Adam D.
    Stewart, A. Keith
    Hari, Parameswaran
    Htut, Myo
    O'Donnell, Elizabeth
    Munshi, Nikhil C.
    Avigan, David E.
    Deol, Abhinav
    Lesokhin, Alexander M.
    Singh, Indrajeet
    Zudaire, Enrique
    Yeh, Tzu-Min
    Allred, Alicia J.
    Olyslager, Yunsi
    Banerjee, Arnob
    Goldberg, Jenna D.
    Schecter, Jordan M.
    Jackson, Carolyn C.
    Deraedt, William
    Zhuang, Sen Hong
    Infante, Jeffrey R.
    Geng, Dong
    Wu, Xiaoling
    Carrasco, Marlene J.
    Akram, Muhammad
    Hossain, Farah
    Rizvi, Syed
    Fan, Frank
    Jagannath, Sundar
    Lin, Yi
    Martin, Thomas, III
    BLOOD, 2020, 136
  • [50] A phase 1, first-in-human (FIH) study of autologous macrophages engineered to express an anti-HER2 chimeric antigen receptor (CAR) in participants (pts) with HER2-overexpressing solid tumors
    Abdou, Yara
    Dees, Elizabeth Claire
    Mortimer, Joanne E.
    Pohlmann, Paula R.
    Johnson, Melissa Lynne
    Maziarz, Richard T.
    Specht, Jennifer M.
    Yuan, Yuan
    Ueno, Naoto T.
    Angelos, Mathew
    Gill, Saar
    Ronczka, Amy
    Condamine, Thomas
    Cushing, Daniel
    Barton, Debora
    Klichinsky, Michael
    Swaby, Ramona F.
    Reiss, Kim Anna
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)