Safety Data from a First-in-Human Phase 1 Trial of NKG2D Chimeric Antigen Receptor-T Cells in AML/MDS and Multiple Myeloma

被引：25

作者：

Nikiforow, Sarah ^{[1
,2
]}

Werner, Lillian ^{[3
]}

Murad, Joana ^{[4
]}

Jacobs, Matthew ^{[5
]}

Johnston, Lauren ^{[5
]}

Patches, Sarah ^{[5
]}

White, Randie ^{[5
]}

Daley, Heather ^{[5
]}

Negre, Helene ^{[5
]}

Reder, Jake ^{[4
]}

Sentman, Charles ^{[6
]}

Wade, Terri ^{[4
]}

Schmucker, Adam ^{[4
]}

Lehmann, Frederic Francois ^{[7
]}

Snykers, Sarah ^{[7
]}

Allen, Rachel ^{[7
]}

Dipietro, Heidi ^{[1
]}

Cummings, Kristen ^{[1
]}

Galinsky, Ilene ^{[1
]}

Munshi, Nikhil C. ^{[1
,2
]}

Schlossman, Robert L. ^{[2
]}

Stone, Richard M. ^{[1
,2
]}

Neuberg, Donna S. ^{[3
]}

Soiffer, Robert J. ^{[1
,2
]}

Dranoff, Glenn ^{[1
,2
]}

Ritz, Jerome ^{[1
,2
]}

Baumeister, Susanne H. C. ^{[8
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA USA

[2] Harvard Med Sch, Boston, MA USA

[3] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA USA

[4] Celdara Med LLC, Lebanon, NH USA

[5] Dana Farber Canc Inst, Boston, MA USA

[6] Geisel Sch Med, Dartmouth, NS, Canada

[7] Celyad, Celyad, SA, Australia

[8] Boston Childrens Hosp, Boston, MA USA

来源：

BLOOD | 2016年 / 128卷 / 22期

关键词：

D O I：

10.1182/blood.V128.22.4052.4052

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

4052

引用

页数：5

共 50 条

[1] A first-in-human phase I trial of NKG2D chimeric antigen receptor-T cells in AML/MDS and multiple myeloma
Nikiforow, Sarah
Murad, Joana
Daley, Heather
Negre, Helene
Reder, Jake
Sentman, Charles L.
Lehmann, Frederic
Snykers, Sarah
Allen, Rachel
Galinsky, Ilene
Munshi, Nikhil C.
Stone, Richard M.
Soiffer, Robert
Ritz, Jerome
Baumeister, Susanne H. C.
JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)
[2] Validation of Manufacturing NKG2D Chimeric Antigen Receptor T Cells for a First-In-Human Clinical Trial in AML/MDS and Multiple Myeloma
Daley, Heather
Nikiforow, Sarah
Murad, Joana
Negre, Helene
Reider, Jake
Sentman, Charles
Snykers, Sarah
Allen, Rachel
Galinsky, Ilene
Munshi, Nikhil
Stone, Richard
Soiffer, Robert
Ritz, Jerome
Baumeister, Suzanne
MOLECULAR THERAPY, 2016, 24 : S31 - S31
[3] NKG2D chimeric antigen receptor-T cells to target GBM.
Dai, Hong-jiu
Yang, Dong
Sun, Bin
Shi, Lan
Zhang, Pei-xian
Zhao, Xu-dong
JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)
[4] Phase I Trial of Autologous CAR T Cells Targeting NKG2D Ligands in Patients with AML/MDS and Multiple Myeloma
Baumeister, Susanne H.
Murad, Joana
Werner, Lillian
Daley, Heather
Trebeden-Negre, Helene
Gicobi, Joanina K.
Schmucker, Adam
Reder, Jake
Sentman, Charles L.
Gilham, David E.
Lehmann, Frederic F.
Galinsky, Ilene
DiPietro, Heidi
Cummings, Kristen
Munshi, Nikhil C.
Stone, Richard M.
Neuberg, Donna S.
Soiffer, Robert
Dranoff, Glenn
Ritz, Jerome
Nikiforow, Sarah
CANCER IMMUNOLOGY RESEARCH, 2019, 7 (01) : 100 - 112
[5] Development of NKG2D chimeric antigen receptor-T cells as targeted therapy of liver cancer
Dai, Hong-jiu
Yang, Dong
Sun, Bin
Jiang, Yu-Bo
Jia, Ru
Xu, Jian-Ming
JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)
[6] Chimeric NKG2D receptor-expressing T cells as an immunotherapy for multiple myeloma
Barber, Amorette
Zhang, Tong
Megli, Christina J.
Wu, Jillian
Meehan, Kenneth R.
Sentman, Charles L.
EXPERIMENTAL HEMATOLOGY, 2008, 36 (10) : 1318 - 1328
[7] Prediction of First-in-Human Dose of Chimeric Antigen Receptor-T (CAR-T) Cells from Mice
Mahmood, Iftekhar
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2024, 49 (06) : 715 - 722
[8] Treatment of multiple myeloma with adoptively transferred chimeric NKG2D receptor-expressing T cells
A Barber
K R Meehan
C L Sentman
Gene Therapy, 2011, 18 : 509 - 516
[9] Treatment of multiple myeloma with adoptively transferred chimeric NKG2D receptor-expressing T cells
Barber, A.
Meehan, K. R.
Sentman, C. L.
GENE THERAPY, 2011, 18 (05) : 509 - 516
[10] Development of NKG2D-based chimeric antigen receptor-T cells for gastric cancer treatment
Tao, Kelong
He, Meng
Tao, Feng
Xu, Guangen
Ye, Minfeng
Zheng, Yuanyuan
Li, Yaoqing
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2018, 82 (05) : 815 - 827

← 1 2 3 4 5 →