Hallmarks of triple negative breast cancer emerging at last?

被引：38

作者：

Bernardi, Rosa ^{[1
]}

Gianni, Luca ^{[2
]}

机构：

[1] Ist Sci San Raffaele, Div Mol Oncol, I-20132 Milan, Italy

[2] Hosp San Raffaele, Dept Med Oncol, I-20132 Milan, Italy

来源：

CELL RESEARCH | 2014年 / 24卷 / 08期

关键词：

D O I：

10.1038/cr.2014.61

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Triple negative breast cancers (TNBC) are clinically heterogeneous but mostly aggressive malignancies devoid of expression of the estrogen, progesterone and HER2 (ERBB2 or NEU) receptors. Recent evidence shows that basal endoplasmic reticulum stress (ERS) is typically activated in TNBC and cooperates with hypoxia signaling to promote tumor progression and relapse; ERS and hypoxia response may therefore be among the long-searched hallmarks of TNBC.

引用

页码：904 / 905

页数：2

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