Metal-Free sp3 C-H Functionalization: PABS/I2-Promoted Synthesis of Polysubstituted Oxazole Derivatives from Arylethanones and 2-Amino-2-alkyl/arylacetic Acid

被引：20
|
作者：
Hu, Ting [1 ]
Yan, Hao [2 ]
Liu, Xingxing [1 ]
Wu, Chaoyang [1 ]
Fan, Yuxing [1 ]
Huang, Jing [3 ,4 ]
Huang, Guosheng [1 ]
机构：
[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
[2] Shaanxi Univ Chinese Med, Coll Pharm, Xianyang 712046, Shaanxi Provinc, Oman
[3] Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA
[4] Virginia Tech, Macromol & Interfaces Inst, Blacksburg, VA 24061 USA
来源：
SYNLETT | 2015年 / 26卷 / 20期
关键词：
nonmetal-catalyzed; oxazoles; sp(3) C-H functionalization; high yield; amino acids; DOMINO OXIDATIVE CYCLIZATION; THIAZOLE; IMIDAZOLE; CYCLOISOMERIZATION; MUSCARINE; ALKALOIDS;
D O I：
10.1055/s-0035-1560660
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A nonmetal-catalyzed process for the synthesis of polysubstituted oxazoles from inexpensive and readily available -amino acids and methyl ketones is established. This reaction is proposed to achieve oxidative cleavage of C(sp(3))-H bonds, followed by decarboxylation and annulation. The mild reaction conditions employed in both cases enable the tolerance of a wide range of functional groups as well as high reaction efficiency.
引用
收藏
页码：2866 / 2869
页数：4
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