Effects of endothelin-1 on the secretory capacity and proliferative activity of regenerating rat adrenal cortex

被引:0
|
作者
Malendowicz, LK
Belloni, AS
Nussdorfer, GG
Hochol, A
Markowska, A
Trejter, M
机构
[1] UNIV PADUA,DEPT ANAT,I-35121 PADUA,ITALY
[2] SCH MED,DEPT HISTOL & EMBRIOL,PL-60781 POZNAN,POLAND
来源
MEDICAL SCIENCE RESEARCH | 1997年 / 25卷 / 04期
关键词
endothelin-1; adrenal cortex; adrenal regeneration; steroid secretion;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
We investigated the effect of endothelin-l (ET-1) on the secretory capacity and proliferative activity of regenerating rat adrenals. Rats underwent left adrenal enucleation and contralateral adrenalectomy and were decapitated 4, 6 or 8 days after surgery. Animals were given two subcutaneous injection of 2 nmol kg(-1) ET-1, 24 and 12 h before decapitation, as well as 100 mg/100g vincristine 180 min before autopsy. At all the regeneration times tested, plasma aldosterone and corticosterone concentrations and adrenal mitotic index (% of metaphase-arrested cells) were significantly higher in ET-l-treated rats than in control animals. The conclusion is drawn that ET-1 stimulates the regeneration of enucleated adrenals in rats.
引用
收藏
页码:225 / 226
页数:2
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