A pilot study of megestrol acetate and ibuprofen in the treatment of cachexia in gastrointestinal cancer patients

被引：47
|
作者：
McMillan, DC [1 ]
OGorman, P [1 ]
Fearon, KCH [1 ]
McArdle, CS [1 ]
机构：
[1] UNIV EDINBURGH,ROYAL INFIRM,DEPT SURG,EDINBURGH EH3 9YW,MIDLOTHIAN,SCOTLAND
来源：
BRITISH JOURNAL OF CANCER | 1997年 / 76卷 / 06期
关键词：
gastrointestinal cancer; weight loss; megestrol acetate; ibuprofen; acute-phase response;
D O I：
10.1038/bjc.1997.463
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Advanced gastrointestinal cancer patients with weight loss and an acute-phase response (n = 15) were given megestrol acetate (480 mg day(-1)) and ibuprofen (1200 mg day(-1)) for 6 weeks. Overall, there was an increase in body weight (P = 0.01) and a reduction in C-reactive protein concentrations (P = 0.02), with no change in total body water (P = 0.24) over this period. This regimen may be an effective non-toxic treatment for cancer cachexia and is worthy of further study.
引用
收藏
页码：788 / 790
页数：3
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