Elevated creatinine after ingestion of model aviation fuel: Interference with the Jaffe reaction by nitromethane

被引：14

作者：

Booth, CJ

Naidoo, D

Rosenberg, AR ^{[1
]}

Kainer, G

机构：

[1] Sydney Childrens Hosp, Dept Nephrol, Randwick, NSW, Australia

[2] Prince Wales Hosp, Dept Clin Chem, Randwick, NSW 2031, Australia

来源：

JOURNAL OF PAEDIATRICS AND CHILD HEALTH | 1999年 / 35卷 / 05期

关键词：

aviation fuel; creatinine; Jaffe reaction; nitromethane;

D O I：

10.1046/j.1440-1754.1999.355402.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

A 2 years 9 month-old-boy who ingested model aviation fuel was found to have an elevated serum creatinine concentration of 0.53 mmol/L (normal range 0.02-0.05 mmol/L) by the Jaffe (alkaline picrate) reaction. However, when the creatinine concentration was measured using a specific enzymatic assay, it was within the normal range. It was shown that nitromethane, a constituent of aviation fuel, interferes with the Jaffe reaction, leading to a falsely elevated creatinine reading. This phenomenon has been reported only once previously and, despite its potential clinical importance, nitromethane does not appear in published lists of substances that interfere with the Jaffe reaction.

引用

页码：503 / 504

页数：2