A photochemical method for determining plasma homocysteine with limited sample processing

被引：20
|
作者：
Hakuna, Lovemore [1 ]
Escobedo, Jorge O. [1 ]
Lowry, Mark [1 ]
Barve, Aabha [1 ]
McCallum, Naneki [1 ]
Strongin, Robert M. [1 ]
机构：
[1] Portland State Univ, Dept Chem, Portland, OR 97207 USA
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 23期
基金：
美国国家卫生研究院;
关键词：
THIYL RADICALS; THIOLS; CHEMOSENSORS; COBALAMIN; CYSTEINE; KINETICS;
D O I：
10.1039/c4cc00432a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The photolytic formation of thiyl radicals allows for the selective detection of total homocysteine (tHcy) in plasma after reduction and filtering. The mechanism is based on the reduction of viologens by the alpha-amino carbon centred radical of Hcy generated by intramolecular hydrogen atom transfer (HAT) of its thiyl radical.
引用
收藏
页码：3071 / 3073
页数：3
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