Lateral epicondylitis is the most common cause of elbow pain in patients presenting to orthopaedic surgeons. While physical therapy, NSAIDs, and activity modification are the mainstay of treatment, other modalities have been used successfully, including many injectable substances. While surgery is reserved for patients with refractory symptoms after failed nonoperative management, good results can be anticipated with most of the reported techniques, including open debridement, arthroscopic debridement, or percutaneous release. Copyright © 2009 SLACK Incorporated. All rights reserved.