Toxic Myopathies

被引：36
|
作者：
Pasnoor, Mamatha [1 ]
Barohn, Richard J. [1 ]
Dimachkie, Mazen M. [1 ]
机构：
[1] Univ Kansas, Med Ctr, Dept Neurol, Kansas City, KS 66160 USA
来源：
NEUROLOGIC CLINICS | 2014年 / 32卷 / 03期
关键词：
Toxic myopathies; Muscle tissue; Statins; Myopathy; EOSINOPHILIA-MYALGIA-SYNDROME; PENICILLAMINE-INDUCED MYOSITIS; DRUG-INDUCED MYOPATHIES; CREATINE-KINASE LEVELS; COLCHICINE MYONEUROPATHY; CORTICOSTEROID MYOPATHY; MITOCHONDRIAL TOXICITY; MALIGNANT HYPERTHERMIA; ZIDOVUDINE MYOPATHY; VACUOLAR MYOPATHY;
D O I：
10.1016/j.ncl.2014.04.009
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Muscle tissue is highly sensitive to many substances. Early recognition of toxic myopathies is important, because they potentially are reversible on removal of the offending drug or toxin, with greater likelihood of complete resolution the sooner this is achieved. Clinical features range from mild muscle pain and cramps to severe weakness with rhabdomyolysis, renal failure, and even death. The pathogenic bases can be multifactorial. This article reviews some of the common toxic myopathies and their clinical presentation, histopathologic features, and possible underlying cellular mechanisms.
引用
收藏
页码：647 / +
页数：25
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