Three-component coupling of alkynes, Baylis-Hillman adducts and sodium azide: a new synthesis of substituted triazoles

被引：34
|
作者：
Chandrasekhar, S [1 ]
Basu, D [1 ]
Rambabu, C [1 ]
机构：
[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India
来源：
TETRAHEDRON LETTERS | 2006年 / 47卷 / 18期
关键词：
multi-component coupling; click synthesis; triazoles; Baylis-Hillman adduct; terminal alkynes;
D O I：
10.1016/j.tetlet.2006.03.037
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A three-component coupling was used to prepare a series of 1,4-disubstituted-1,2,3-triazoles from the corresponding acetylated Baylis-Hillman adducts, sodium azide and terminal alkynes. This one-pot reaction further increases the efficacy of 'Click' synthesis and diversifies the preparation of multi-functional 1,4-disubstituted-1,2,3-triazoles. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3059 / 3063
页数：5
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