An adaptive compensation control law is designed for a class of multi-input multi-output (MIMO) nonlinear minimum phase systems with actuator failures. Based on the differential geometry feedback linearization method, PPB and backstepping technique, an adaptive compensation tracking control scheme is designed for the system with actuators lock in space and loss of effectiveness failures. The proposed control law can guarantee that the closed-loop system with actuator failures is stability and asymptotically tracks the given reference signals, and the system transient performance is guaranteed. Simulation results demonstrate the effectiveness of the proposed method.