CHANGES AND SIGNIFICANCE OF CYSTATIN C IN URINE OF RATS WITH ISCHEMIA/ REPERFUSION ACUTE KIDNEY INJURY

被引:0
|
作者
Tao, Xiaoyang [1 ,2 ]
Yu, Shengqiang [1 ]
机构
[1] Shanghai Changzheng Hosp, Shanghai 200003, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 9, Huangpu Branch, Shanghai 200003, Peoples R China
来源
ACTA MEDICA MEDITERRANEA | 2022年 / 38卷 / 06期
关键词
Cystatin C; ischemia/reperfusion acute kidney injury; rat urine; significance analysis;
D O I
10.19193/0393-6384_2022_6_550
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: As incidences of kidney disease increase, patients with this disease are prone to ischemia/reperfusion acute kidney injury after surgery; this not only affects their quality of life after surgery, but also increases the burden on their kidneys. Cystatin C (Cys C) plays an important role in the treatment of ischemia/reperfusion acute kidney injury (AKI) disease. Therefore, it is necessary to study the role of Cys C in the progression of AKI disease. The purposes of this article are to analyse the changes and significance of Cys C in the urine of rats with ischemia/reperfusion AKI and to establish a rat model of ischemia/reperfusion AKI. Methods: According to their perfusion time, the rats were divided into four groups: 0, 10, 20, and 30 min. Next, the urine Cys C and renal tubular necrosis score were measured. Results: The results of the study show that the baseline urine Cys C levels of rats in each group were in the vicinity of 0.29, 0.79, 1.22, and 1.32 mu g/L, respectively. After 24 hours of reperfusion, the level of urinary Cys C in the 0-min renal ischemia group did not change significantly, while the level of urinary Cys C increased significantly in the 10-, 20-, and 30-min renal ischemia groups. Conclusion: It is evident that changes of Cys C in the urine of rats with ischemia/reperfusion acute kidney injury is of great significance for the detection of AKI.
引用
收藏
页码:3769 / 3777
页数:9
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