The role of endocan and immature granulocyte in the diagnosis of acute pancreatitis

Aim: Acute pancreatitis is an inflammatory disease. It can progress from mild forms to serious life-threatening cases. Early diagnosis and treatment are critical for prognosis. In this study, we aimed to investigate whether serum endocan, immature granulocyte percentage (IG%) and CRP (C Reactive Protein) could be used as biomarkers in the early diagnosis of acute pancreatitis.Material and Method: Patients diagnosed with AP (n=90) and individuals diagnosed with biliary obstruction due to choledochal stones (but not developed AP) (n=90) were included in this study. Serum endocan, IG% and CRP levels were measuredResults: Endocan, IG and CRP were found to be significantly higher in AP patients compared to controls (p<0.0001). According to the ROC analysis result, CRP (AUROC: 0.997) can be used to estimate AP, but endocan (AUROC: 0.638) and IG% (AUROC: 0.626) sensitivity-specificity is lowDiscussion: CRP is an effective marker in the diagnosis of AP. Endocan and IG% are not effective in the diagnosis of AP because their sensitivity-specificity is low in the diagnosis of AP.