A Novel Peptide from Polypedates megacephalus Promotes Wound Healing in Mice

被引：6
|
作者：
Fu, Siqi [1 ]
Du, Canwei [2 ]
Zhang, Qijian [3 ]
Liu, Jiayu [4 ]
Zhang, Xushuang [4 ]
Deng, Meichun [4 ,5 ,6 ]
机构：
[1] Cent South Univ, Xiangya Hosp 2, Dept Dermatol, Hunan Key Lab Med Epigen, Changsha 410013, Peoples R China
[2] Chengdu Pep Biomed Co Ltd, Chengdu 610041, Peoples R China
[3] Cent South Univ, Wound Ctr, Xiangya Hosp, Changsha 410013, Peoples R China
[4] Cent South Univ, Sch Life Sci, Dept Biochem & Mol Biol, Hunan Prov Key Lab Basic & Appl Hematol, Changsha 410013, Peoples R China
[5] Cent South Univ, Sch Life Sci, Hunan Key Lab Anim Models Human Dis, Changsha 410013, Peoples R China
[6] Cent South Univ, Sch Life Sci, Hunan Key Lab Med Genet, Changsha 410013, Peoples R China
来源：
TOXINS | 2022年 / 14卷 / 11期
基金：
中国国家自然科学基金;
关键词：
frogs; peptides; skin wounds; HSF cells; HUVEC cells; ANTIMICROBIAL PEPTIDES; SKIN; INSULIN;
D O I：
10.3390/toxins14110753
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Amphibian skin contains wound-healing peptides, antimicrobial peptides, and insulin-releasing peptides, which give their skin a strong regeneration ability to adapt to a complex and harsh living environment. In the current research, a novel wound-healing promoting peptide, PM-7, was identified from the skin secretions of Polypedates megacephalus, which has an amino acid sequence of FLNWRRILFLKVVR and shares no structural similarity with any peptides described before. It displays the activity of promoting wound healing in mice. Moreover, PM-7 exhibits the function of enhancing proliferation and migration in HUVEC and HSF cells by affecting the MAPK signaling pathway. Considering its favorable traits as a novel peptide that significantly promotes wound healing, PM-7 can be a potential candidate in the development of novel wound-repairing drugs.
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页数：9
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