Synthesis and biological activity of mycalolide analogs

被引：28

作者：

Suenaga, Kiyotake ^{[1
]}

Kimura, Tomoyuki ^{[1
]}

Kuroda, Takeshi ^{[1
]}

Matsui, Keita ^{[1
]}

Miya, Saori ^{[1
]}

Kuribayashi, Satomi ^{[1
]}

Sakakura, Akira ^{[1
]}

Kigoshi, Hideo ^{[1
]}

机构：

[1] Univ Tsukuba, Dept Chem, Tsukuba, Ibaraki 3058571, Japan

来源：

TETRAHEDRON | 2006年 / 62卷 / 35期

基金：

日本学术振兴会;

关键词：

D O I：

10.1016/j.tet.2006.06.046

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Mycalolide analog 4, consisting only of the side chain of mycalolide B (2), a trisoxazole macrolide of marine origin, was stereoselectively synthesized using Roush crotylboration, an Evans aldol reaction, and a Paterson aldol reaction as key steps. The analog 4 was found to have strong actin-depolymerizing activity. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：8278 / 8290

页数：13

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