Target-Based Drug Discovery: the Emerging Success of Frontal Affinity Chromatography Coupled to Mass Spectrometry

被引：33
|
作者：
Calleri, Enrica [1 ]
Temporini, Caterina [1 ]
Caccialanza, Gabriele [1 ]
Massolini, Gabriella [1 ]
机构：
[1] Univ Pavia, Dipartimento Chim Farmaceut, I-27100 Pavia, Italy
来源：
CHEMMEDCHEM | 2009年 / 4卷 / 06期
关键词：
drug discovery; high-throughput screening; binding assays; mass spectrometry; FAC-MS; IMMOBILIZED P-GLYCOPROTEIN; RECEPTOR STATIONARY-PHASE; SMALL-MOLECULE INHIBITORS; TYROSINE KINASE RECEPTOR; LIQUID-CHROMATOGRAPHY; MS DETECTION; SCREENING TECHNIQUES; BINDING AFFINITIES; LEAD GENERATION; FAC-MS;
D O I：
10.1002/cmdc.200800436
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：905 / 916
页数：12
相关论文
共 50 条
  • [31] Discovery of Emerging Disinfection by-products in Water using Gas Chromatography coupled with Orbitrap-based Mass Spectrometry
    Cojocariu, Cristian
    Postigo, Cristina
    Richardson, Susan D.
    Barcelo, Damia
    Silcock, Paul
    BRAZILIAN JOURNAL OF ANALYTICAL CHEMISTRY, 2019, 6 (22): : 98 - 105
  • [32] Rapid determination of the binding affinity and specificity of the mushroom Polyporus squamosus lectin using frontal affinity chromatography coupled to electrospray mass spectrometry
    Zhang, BY
    Palcic, MM
    Mo, HQ
    Goldstein, IJ
    Hindsgaul, O
    GLYCOBIOLOGY, 2001, 11 (02) : 141 - 147
  • [33] Frontal affinity chromatography with MS detection (FAC-MS) in drug discovery
    Slon-Usakiewicz, JJ
    Ng, W
    Dai, JR
    Pasternak, A
    Redden, PR
    DRUG DISCOVERY TODAY, 2005, 10 (06) : 409 - 416
  • [34] An in Silico Approach for Integrating Phenotypic and Target-Based Approaches in Drug Discovery
    Iwata, Hiroaki
    Kojima, Ryosuke
    Okuno, Yasushi
    MOLECULAR INFORMATICS, 2020, 39 (1-2)
  • [35] Triazole-fused pyrimidines in target-based anticancer drug discovery
    Dai, Xing-Jie
    Xue, Lei-Peng
    Ji, Shi-Kun
    Zhou, Ying
    Gao, Ya
    Zheng, Yi-Chao
    Liu, Hui-Min
    Liu, Hong-Min
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 249
  • [36] Bridging the gap between target-based and phenotypic-based drug discovery
    Calado, Cecilia R. C.
    EXPERT OPINION ON DRUG DISCOVERY, 2024, 19 (07) : 789 - 798
  • [37] Drug Discovery in the Age of Artificial Intelligence: Transformative Target-Based Approaches
    Patne, Akshata Yashwant
    Dhulipala, Sai Madhav
    Lawless, William
    Prakash, Satya
    Mohapatra, Shyam S.
    Mohapatra, Subhra
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (22)
  • [38] Reductionism and proxy failure: From neuroscience to target-based drug discovery
    Sadri, Arash
    Paknezhad, Sepideh
    BEHAVIORAL AND BRAIN SCIENCES, 2024, 47
  • [39] Drug Discovery for Neglected Diseases: Molecular Target-Based and Phenotypic Approaches
    Gilbert, Ian H.
    JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (20) : 7719 - 7726
  • [40] Strategic use of affinity-based mass spectrometry techniques in the drug discovery process
    Kelly, MA
    McLellan, TJ
    Rosner, PJ
    ANALYTICAL CHEMISTRY, 2002, 74 (01) : 1 - 9
12345