Copper-mediated C-H(sp2)/C-H(sp3) coupling of benzoic acid derivatives with ethyl cyanoacetate: an expedient route to an isoquinolinone scaffold

被引：52
|
作者：
Zhu, Wei [1 ]
Zhang, Dengyou [1 ]
Yang, Nan [1 ]
Liu, Hong [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 73期
基金：
中国国家自然科学基金;
关键词：
C-H BONDS; DIRECT FUNCTIONALIZATION; DIRECTING GROUP; ACTIVATION; ARYL; ARYLATION; ARENE; ALKALOIDS; HALIDES;
D O I：
10.1039/c4cc03837a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A facile, copper-mediated, direct C-H(sp(2))/C-H(sp(3)) bond coupling of benzoic acid derivatives with ethyl cyanoacetate by the deployment of an 8-aminoquinoline moiety as a bidentate directing group is disclosed. Such a unique transformation provides a new strategy for the construction of an isoquinolinone scaffold as one of the privileged cores.
引用
收藏
页码：10634 / 10636
页数：3
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