Chimeric Antigen Receptor T-Cells New Approaches to Improve Their Efficacy and Reduce Toxicity

被引：8
|
作者：
Maus, Marcela V. [1 ,2 ]
Powell, Daniel J., Jr. [2 ,3 ,4 ]
机构：
[1] Univ Penn, Div Hematol Oncol, Dept Med, Perelman Sch Med, Philadelphia, PA 19104 USA
[2] Univ Penn, Abramson Canc Ctr, Perelman Sch Med, Philadelphia, PA 19104 USA
[3] Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA
[4] Univ Penn, Dept Obstet & Gynecol, Perelman Sch Med, Philadelphia, PA 19104 USA
来源：
CANCER JOURNAL | 2015年 / 21卷 / 06期
关键词：
Adoptive transfer; chimeric antigen receptor; genetic engineering; immunotherapy; T-cell; toxicity; ANTITUMOR-ACTIVITY; ADOPTIVE IMMUNOTHERAPY; CYTOKINE RELEASE; CANCER; COSTIMULATION; MEMORY; POTENT; CD28; LYMPHODEPLETION; PERSISTENCE;
D O I：
10.1097/PPO.0000000000000155
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The durable remission of B-cell leukemia and lymphoma following chimeric antigen receptor (CAR) T-cell therapy has brought this new form of adoptive immunotherapy to center stage with the expectation that CAR T-cell therapy may provide similar efficacy in other hematologic and solid cancers. Herein, we review recent advances in the areas of CAR design that improve CAR T-cell proliferation, engraftment, and efficacy, as well as clinical application strategies that are designed to improve clinical efficacy while reducing the risk of toxicity and broaden patient access to this promising form of cancer immunotherapy.
引用
收藏
页码：475 / 479
页数：5
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