Graft failure after allogeneic hematopoietic stem cell transplantation: Definition and risk factors

被引：1
|
作者：
Alcazer, Vincent [1 ,2 ]
de Latour, Regis Peffault [3 ,4 ]
Ader, Florence [5 ,6 ]
Labussiere-Wallet, Helene [1 ]
机构：
[1] Hosp Civils Lyon, Dept Hematol Clin, 165 Chemin Grand Revoyet, F-69310 Pierre Benite, France
[2] Ctr Rech Cancerol Lyon, Inserm U1052, CNRS 5286, F-69008 Lyon, France
[3] Hop St Louis, AP HP, Serv Hematol Greffe, F-75006 Paris, France
[4] Univ Paris Diderot, F-75007 Paris, France
[5] Hosp Civils Lyon, Serv Malad Infect, F-69004 Lyon, France
[6] Ctr Int Rech Infectiol, Inserm U1111, CNRS 5308, F-69008 Lyon, France
来源：
BULLETIN DU CANCER | 2019年 / 106卷 / 06期
关键词：
Allogeneic hematopoietic; stem cell transplantation; Graft failure; Rejection; Infections; ANTI-HLA ANTIBODIES; BONE-MARROW-TRANSPLANTATION; PERIPHERAL-BLOOD; RETROSPECTIVE ANALYSIS; FRANCOPHONE SOCIETY; APLASTIC-ANEMIA; DONOR; IMPACT; OUTCOMES; ENGRAFTMENT;
D O I：
10.1016/j.bulcan.2019.03.009
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Allogeneic hematopoietic stem cell transplantation is the only curative therapy for numerous malignant and non-malignant haematological diseases. A sustained engraftment of the donor stem cells is essential for transplant success and overall outcome. Graft failure is a rare but severe event after allogeneic hematopoietic stem cell transplantation. While different risk factors such as underlying disease, graft source or HLA matching have been found to be consistently associated with graft failure, other factors such as ABO mismatch graft-versus-host disease prophylaxis or infections, particularly viral reactivations, are more controversial. In this article, we review the different factors associated with graft failure.
引用
收藏
页码：574 / 583
页数：10
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