Failure to confirm association between AKT1 haplotype and schizophrenia in a Japanese case-control population

AKT1 is a serine/threonine kinase known as protein kinase B. AKT/glycogen synthase kinase 3 (GSK-3) signaling pathway might be relevant to dopamine-related disorders. Recently, AKT1 was identified as a potential schizophrenia susceptibility gene in families of northern European origin. In this study, the authors attempted to confirm the association between AKT1 haplotypes and schizophrenia in a Japanese case-control population consisting of 1126 individuals. The authors observed no significant allelic or haplotypic association.