GTP, an inhibitor of transglutaminases, is hydrolyzed by tissue-type transglutaminase (TGase 2) but not by epidermal-type transglutaminase (TGase 3)

被引：13
|
作者：
Hitomi, K [1 ]
Ikura, K
Maki, M
机构：
[1] Nagoya Univ, Grad Sch Bioagr Sci, Dept Appl Mol Biosci, Nagoya, Aichi 4648601, Japan
[2] Kyoto Inst Technol, Fac Text Sci, Dept Appl Biol, Kyoto 606, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2000年 / 64卷 / 03期
关键词：
transglutaminase; GTP; GTPase; calcium;
D O I：
10.1271/bbb.64.657
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Epidermal-type transglutaminase (TGase 3) is devoid of GTPase activity, but its TGase activity is inhibited by GTP as in the case of tissue-type TGase (TGase 2). In addition, the inhibition was not affected by the presence of higher concentrations of Ca ion. These results indicate that GTP interacts with TGase 3 in a manner different from its action on TGase 2.
引用
收藏
页码：657 / 659
页数：3
相关论文
共 50 条
  • [21] TISSUE-TYPE TRANSGLUTAMINASE IS NOT A TUMOR-RELATED MARKER
    TAKAKU, K
    FUTAMURA, M
    SAITOH, S
    TAKEUCHI, Y
    JOURNAL OF BIOCHEMISTRY, 1995, 118 (06): : 1268 - 1270
  • [22] Small artery remodeling depends on tissue-type transglutaminase
    Bakker, ENTP
    Buus, CL
    Spaan, JAE
    Perree, J
    Ganga, A
    Rolf, TM
    Sorop, O
    Bramsen, LH
    Mulvany, MJ
    VanBavel, E
    CIRCULATION RESEARCH, 2005, 96 (01) : 119 - 126
  • [23] INCREASED EXPRESSION OF TISSUE TRANSGLUTAMINASE (TGASE) GENE FOLLOWING POLYAMINE DEPLETION IN CACO-2 CELLS
    WANG, JY
    VIAR, MJ
    JOHNSON, LR
    GASTROENTEROLOGY, 1995, 108 (04) : A551 - A551
  • [24] Silencing Transglutaminase Genes TGase2 and TGase3 Has Infection-Dependent Effects on the Heart Rate of the Mosquito Anopheles gambiae
    Ramakrishnan, Abinaya
    Hillyer, Julian F.
    INSECTS, 2022, 13 (07)
  • [25] The mouse wellhaarig (we) mutations result from defects in epidermal-type transglutaminase 3 (Tgm3)
    Brennan, Brett M.
    Huynh, Minh T.
    Rabah, Mohammed A.
    Shaw, Hailie E.
    Bisaillon, Jason J.
    Radden, Legairre A., II
    Nguyen, Tu V.
    King, Thomas R.
    MOLECULAR GENETICS AND METABOLISM, 2015, 116 (03) : 187 - 191
  • [26] A novel function of tissue-type transglutaminase: protein disulphide isomerase
    Hasegawa, G
    Suwa, M
    Ichikawa, Y
    Ohtsuka, T
    Kumagai, S
    Kikuchi, M
    Sato, Y
    Saito, Y
    BIOCHEMICAL JOURNAL, 2003, 373 : 793 - 803
  • [27] Expression of GTP-dependent and GTP-independent tissue-type transglutaminase in cytokine-treated rat brain astrocytes
    Monsonego, A
    Shani, Y
    Friedmann, I
    Paas, Y
    Eizenberg, O
    Schwartz, M
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (06) : 3724 - 3732
  • [28] Vascular inward remodeling is delayed in mice deficient for tissue-type transglutaminase
    Bakker, EN
    Pistea, A
    Spaan, J
    VanBavel, E
    FASEB JOURNAL, 2005, 19 (04): : A160 - A160
  • [29] A vascular bone collector - Arterial calcification requires tissue-type transglutaminase
    VanBavel, Ed
    Bakker, Erik N. T. P.
    CIRCULATION RESEARCH, 2008, 102 (05) : 507 - 509
  • [30] Increase tissue-type transglutaminase in experimental encapsulating peritoneal sclerosis.
    Oseto, S
    Ito, T
    Suzuki, A
    Nagatoya, K
    Imai, E
    Hori, M
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2003, 14 : 891A - 891A
12345