Recent advances in electrospun nanofibers for wound healing

被引:265
|
作者
Chen, Shixuan [1 ,2 ]
Liu, Bing [1 ,2 ,3 ]
Carlson, Mark A. [4 ,5 ,6 ,7 ]
Gombart, Adrian F. [8 ,9 ]
Reilly, Debra A. [10 ,11 ]
Xie, Jingwei [1 ,2 ]
机构
[1] Univ Nebraska Med Ctr, Dept Surg Transplant, Omaha, NE 68198 USA
[2] Univ Nebraska Med Ctr, Mary & Dick Holland Regenerat Med Program, Omaha, NE 68198 USA
[3] China Med Univ, Affiliated Hosp 1, Dept Anorectal Surg, Shenyang 110001, Liaoning, Peoples R China
[4] Univ Nebraska Med Ctr, Dept Surg & Genet, Omaha, NE 68198 USA
[5] Univ Nebraska Med Ctr, Dept Cell Biol, Omaha, NE 68198 USA
[6] Univ Nebraska Med Ctr, Dept Anat, Omaha, NE 68198 USA
[7] VA Nebraska Western Iowa Hlth Care Syst, Dept Surg, Omaha, NE 68105 USA
[8] Oregon State Univ, Dept Biochem & Biophys, Corvallis, OR 97331 USA
[9] Oregon State Univ, Linus Pauling Inst, Corvallis, OR 97331 USA
[10] Univ Nebraska Med Ctr, Dept Plast Surg, Omaha, NE 68198 USA
[11] Univ Nebraska Med Ctr, Dept Reconstruct Surg, Omaha, NE 68198 USA
关键词
electrospun nanofibers; local drug de very; scaffold; skin regeneration; wound healing; HYPERTROPHIC SCAR CONTRACTION; NORMAL HUMAN KERATINOCYTES; HUMAN DERMAL FIBROBLASTS; MESENCHYMAL STEM-CELLS; DRUG-RELEASE; SKIN SUBSTITUTES; GROWTH-FACTORS; ANTIBACTERIAL ACTIVITY; COMPOSITE NANOFIBERS; EXTRACELLULAR-MATRIX;
D O I
10.2217/nnm-2017-0017
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Electrospun nanofibers represent a novel class of materials that show great potential in many biomedical applications including biosensing, regenerative medicine, tissue engineering, drug delivery and wound healing. In this work, we review recent advances in electrospun nanofibers for wound healing. This article begins with a brief introduction on the wound, and then discusses the unique features of electrospun nanofibers critical for wound healing. It further highlights recent studies that have used electrospun nanofibers for wound healing applications and devices, including sutures, multifunctional dressings, dermal substitutes, engineered epidermis and full thickness skin regeneration. Finally, we finish with conclusions and future perspective in this field.
引用
收藏
页码:1335 / 1352
页数:18
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