Strategies for analyzing genotype-phenotype relationships in asthma

被引：5
|
作者：
Wiesch, DG [1 ]
Meyers, DA [1 ]
机构：
[1] Univ Maryland, Sch Med, Ctr Genet Asthma & Complex Dis, Baltimore, MD 21201 USA
来源：
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2000年 / 105卷 / 02期
关键词：
genotype; phenotype; asthma; complex disease; mendelian disease; breast cancer; cystic fibrosis; case-control study; gene-environment interaction;
D O I：
10.1016/S0091-6749(00)90047-2
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Asthma is a genetically complex disease with a multifaceted phenotype, Different approaches including population-based and family-based methods for evaluating genotype-phenotype relationships in asthma are discussed as well as the problems that may obscure these determinations. Examples of similar efforts in cystic fibrosis and breast cancer are considered in addition to interaction between causative genes and etiologically relevant environmental exposure.
引用
收藏
页码：S482 / S486
页数：5
相关论文
共 50 条
  • [31] Emerging Genotype-Phenotype Relationships in Primary Ciliary Dyskinesia
    Brennan, Steven K.
    Ferkol, Thomas W.
    Davis, Stephanie D.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (15)
  • [32] Genotype-phenotype relationships in congenital long QT syndrome
    Ackerman, MJ
    JOURNAL OF ELECTROCARDIOLOGY, 2005, 38 (04) : 64 - 68
  • [33] Studying genotype-phenotype relationships: cardiovascular disease as an example
    Herrmann, SM
    Paul, M
    JOURNAL OF MOLECULAR MEDICINE-JMM, 2002, 80 (05): : 282 - 289
  • [34] Exploring complexities in human pigmentation genotype-phenotype relationships
    Norton, Heather L.
    AMERICAN JOURNAL OF BIOLOGICAL ANTHROPOLOGY, 2023, 180 : 129 - 129
  • [35] Genotype-phenotype relationships in Bulgarian Alzheimer's patients
    Mehrabian, S.
    Jordanova, A.
    Raycheva, M.
    Cruts, M.
    Van Broeckhoven, C.
    Traykov, L.
    JOURNAL OF NEUROLOGY, 2010, 257 : S204 - S204
  • [36] Genotype-Phenotype Relationships in Freeman-Sheldon Syndrome
    Beck, Anita E.
    McMillin, Margaret J.
    Gildersleeve, Heidi I. S.
    Shively, Kathryn M. B.
    Tang, Andy
    Bamshad, Michael J.
    AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2014, 164 (11) : 2808 - 2813
  • [37] The dog:: A powerful model for studying genotype-phenotype relationships
    Galibert, Francis
    Andre, Catherine
    COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS, 2008, 3 (01): : 67 - 77
  • [38] PROSPECTIVE SCREENING FOR LIDDLE SYNDROME - GENOTYPE-PHENOTYPE RELATIONSHIPS
    HANSSON, JH
    NELSONWILLIAMS, C
    SHIMKETS, R
    FINDLING, J
    RAFF, H
    WILSON, T
    LIFTON, RP
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1995, 6 (03): : 621 - 621
  • [39] Genotype-phenotype relationships for psychiatric disorders; gender effects
    Heinz, A.
    Friedel, E.
    Schlagenhauf, F.
    Puls, I.
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2010, 20 : S200 - S200
  • [40] cTTP: Genotype-phenotype Correlation and Treatment Strategies Comment
    Andres, Ulrike
    TRANSFUSIONSMEDIZIN, 2019, 9 (03) : 154 - 154
12345