Convenient synthesis of some 2-substituted 4(3H)-quinazolinone derivatives

被引：21

作者：

Philipova, I. ^{[1
]}

Dobrikov, G. ^{[1
]}

Krumova, K. ^{[1
]}

Kaneti, J. ^{[1
]}

机构：

[1] Bulgarian Acad Sci, Ctr Phytochem, Inst Organ Chem, BU-1113 Sofia, Bulgaria

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2006年 / 43卷 / 04期

关键词：

D O I：

10.1002/jhet.5570430436

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 2-substituted-4(3H)-quinazolinones 13-20 has been synthesized in good yields using the reaction of double lithiated 2-methylquinazolinone-4 with a variety of aromatic aldehydes. They have been easily transformed in high yields into the corresponding 2-substituted conjugated derivatives 21-28 bearing terminal aryl groups by F3CCCOH mediated dehydration.

引用

页码：1057 / 1063

页数：7

共 50 条

[1] Synthesis and evaluation of 2-substituted 4(3H)-quinazolinone thioether derivatives as monoamine oxidase inhibitors
Qhobosheane, Malikotsi A.
Petzer, Anel
Petzer, Jacobus P.
Legoabe, Lesetja J.
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 26 (20) : 5531 - 5537
[2] Synthesis of some new tricyclic 4(3H)-quinazolinone derivatives
Jafari, E.
Khodarahmi, G. A.
Hakimelahi, G. H.
Tsai, F. Y.
Hassanzadeh, F.
RESEARCH IN PHARMACEUTICAL SCIENCES, 2011, 6 (02) : 93 - 100
[3] Use of 2-substituted vinyl 4(3H)-quinazolinone and 4H-3,1-benzoxazinone in synthesis of heterocycles
Morsy, J. M.
BULGARIAN CHEMICAL COMMUNICATIONS, 2007, 39 (02): : 146 - 151
[4] Synthesis of some new 2,3-disubstituted-4(3H) quinazolinone derivatives
Hassanzadeh, F.
Khajouei, M. Rahmani
Hakimelahi, G. H.
Jafari, E.
Khodarahmi, G. A.
RESEARCH IN PHARMACEUTICAL SCIENCES, 2012, 7 (01) : 23 - 30
[5] SYNTHESIS OF SOME 3-SUBSTITUTED 4(3H)-QUINAZOLINONE AND 4(3H)-QUINAZOLINETHIONE DERIVATIVES AND RELATED FUSED BIHETEROCYCLIC RING-SYSTEMS
ABDELMEGEED, MF
TENIOU, A
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1988, 53 (02) : 329 - 335
[6] Convenient synthesis of more complex 2-substituted 4(3H)-quinazolinones via lithiation of 2-alkyl-4(3H)-quinazolinones
Smith, K
El-Hiti, GA
Abdel-Megeed, MF
Abdo, MA
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1999, 64 (03) : 515 - 526
[7] Synthesis of 5-bromo-2-substituted-4(3H)-quinazolinone
Liu, Yizhou
Wang, Xinying
Jiao, Linru
Xu, Dongdong
Kang, Congmin
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2017, 56 (03): : 356 - 358
[8] SYNTHESIS AND ANALGESIC EFFICIENCY OF SOME OXY AND OXO DERIVATIVES OF 4(3H)-QUINAZOLINONE
FISNEROVA, L
BRUNOVA, B
KOCFELDOVA, Z
TIKALOVA, J
MATUROVA, E
GRIMOVA, J
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1991, 56 (11A) : 2373 - 2381
[9] SYNTHESIS OF SOME NEW 3-SUBSTITUTED 4(3H)-QUINAZOLINONE AND 4(3H)-QUINAZOLINETHIONE DERIVATIVES AND RELATED FUSED BIHETEROCYCLIC RING-SYSTEMS
ABDELMEGEED, MF
TENIOU, A
REVUE ROUMAINE DE CHIMIE, 1988, 33 (11-12) : 981 - 986
[10] SYNTHESIS OF SOME NOVEL 4(3H)-QUINAZOLINONE DERIVATIVES OF POTENTIAL ANTIMICROBIAL ACTIVITY
ELFEKY, SAH
JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN, 1991, 13 (02): : 107 - 111

← 1 2 3 4 5 →