Acute leukemia of donor origin arising after stem cell transplantation for acute promyelocytic leukemia

被引：13
|
作者：
Daly, AS
Kamel-Reid, S
Lipton, JH
Messner, HA
Kiss, TL
Chun, K
Busque, L
Chang, H
机构：
[1] Univ Toronto, Hlth Network, Princess Margaret Hosp, Dept Lab Hematol, Toronto, ON M5G 2M9, Canada
[2] Univ Toronto, Hlth Network, Princess Margaret Hosp, Dept Med Oncol & Hematol,Allogen Bone Marrow Tran, Toronto, ON M5G 2M9, Canada
[3] Univ Toronto, Hlth Network, Princess Margaret Hosp, Dept Pathol,Dept Cellular & Mol Biol,Ontario Canc, Toronto, ON M5G 2M9, Canada
[4] Univ Montreal, Hosp Maisonneuve Rosemont, Div Hematol, Montreal, PQ H3C 3J7, Canada
来源：
LEUKEMIA RESEARCH | 2004年 / 28卷 / 10期
关键词：
donor cell leukemia; acute promyelocytic leukemia; allogeneic bone marrow transplantation;
D O I：
10.1016/j.leukres.2004.02.003
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We report a patient with PML/RARalpha-positive acute promyelocytic leukemia (APL) who developed PMURARalpha-negative acute myeloid leukemia 37 months after allogeneic bone marrow (BMT) transplant for molecular relapse. Features of myelodysplasia were noted I I months earlier, chimerism testing by analysis of short tandem repeats was consistent with development of myelodysplasia and acute leukemia within cells of donor origin. To our knowledge, this is the first report of donor cell leukemia following BMT for APL. We hypothesize that replicative stress may lead to the development of some cases of donor cell acute leukemia. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1107 / 1111
页数：5
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