Synthesis and anomeric configuration of 2-(erythrofuranosyl)benzimidazole C-nucleoside analogues

被引：18

作者：

Sallam, MAE

Ibrahim, ESI

ElEter, KAA

Cassady, JM

机构：

[1] SUEZ CANAL UNIV,FAC SCI,DEPT CHEM,ISMAILIA,EGYPT

[2] OHIO STATE UNIV,COLL PHARM,COLUMBUS,OH 43210

来源：

CARBOHYDRATE RESEARCH | 1997年 / 298卷 / 1-2期

关键词：

benzimidazole; 2-(erythrofuranosyl)-; benzimidazole C-nucleosides; acyclic-sugar nucleosides;

D O I：

10.1016/S0008-6215(96)00296-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Anomeric 2-(alpha- and beta-D-erythrofuranosyl)benzimidazole C-nucleoside analogues 2 and 3, were prepared from the corresponding epimeric 2-(D-arabino, and D-ribo-tetritol-1-yl)benzimidazole analogues 1 and 4, respectively. Similarly, 2-(beta-L-erythrofuranosyl)benzimidazole 13 was obtained from the precursor 2-(L-arabino-tetritol-1-yl)benzimidazole 12. The structure and anomeric configuration of the C-nucleoside analogues 2, 3, and 13 were determined by acylation, H-1 and C-13 NMR spectroscopy, and mass spectrometry. (C) 1997 Elsevier Science Ltd.

引用

页码：93 / 104

页数：12

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