Evolution of 'Dementia Infantilis to Childhood Disintegrative Disorder, or Autism Spectrum Disorder': A case report

Childhood disintegrative disorder (CDD), rare clinical syndrome characterized by at least two years of normal development, followed by distinct regression of developmental and behavioral functioning before ten years of age. CDD is a condition that no longer officially exists, been eliminated and absorbed into the larger category of autism spectrum disorder with the release of the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Here we report the case of 12 years old male who presented normal development till 4 years of age followed by gradual deterioration in his communication, motor and social skills with behavioral disturbances. The aim of our case report is to increase awareness of this rare illness, due to diagnostic dilemma, especially when no identifiable organic cause is elicited so early diagnosis and prompt treatment required.