Synergistic activity of colistin with azidothymidine against colistin-resistant Klebsiella pneumoniae clinical isolates collected from inpatients in Greek hospitals

被引：16

作者：

Falagas, Matthew E. ^{[1
,2
,3
]}

Voulgaris, Georgios L. ^{[1
,4
]}

Tryfinopoulou, Kyriaki ^{[5
,6
]}

Giakkoupi, Panagiota ^{[5
,6
]}

Kyriakidou, Margarita ^{[1
]}

Vatopoulos, Alkiviadis ^{[5
,6
]}

Coates, Anthony ^{[7
]}

Hu, Yanmin ^{[7
]}

Tsiplakou, S. ^{[8
]}

Papaioannou, V ^{[8
]}

Trikka-Graphakos, E. ^{[9
]}

Charalampakis, N. ^{[9
]}

Sereti, C. ^{[9
]}

Vogiatzakis, E. ^{[10
]}

Moraiti, H. ^{[10
]}

Xanthaki, A. ^{[11
]}

Toutouza, M. ^{[11
]}

Fountoulis, K. ^{[12
]}

Perivolioti, E. ^{[12
]}

Kraniotaki, H. ^{[12
]}

Bournia, M. ^{[12
]}

Vourli, S. ^{[13
]}

Peteinaki, E. ^{[14
]}

Makri, A. ^{[15
]}

Daskalaki, M. ^{[15
]}

Staikou, E. ^{[15
]}

Platsouka, E. ^{[16
]}

Spiliopoulou, I ^{[17
]}

Christofidou, M. ^{[17
]}

Tryfinopoulou, K. ^{[5
,6
]}

Giakkoupi, P. ^{[5
,6
]}

Vatopoulos, A. ^{[5
,6
]}

Vardakas, K. ^{[18
]}

Voulgaris, G. ^{[18
]}

Kyriakidou, M. ^{[18
]}

Falagas, M. ^{[18
]}

机构：

[1] Alfa Inst Biomed Sci, 9 Neapoleos St, Athens 15123, Greece

[2] Henry Dunant Hosp Ctr, Dept Med, Athens, Greece

[3] Tufts Univ, Sch Med, Dept Med, Boston, MA 02111 USA

[4] 401 Gen Mil Hosp, Dept Pharm, Lab Pharmacokinet & Toxicol, Athens, Greece

[5] Natl Sch Publ Hlth, Dept Microbiol, Vari, Greece

[6] Hellen Ctr Dis Control & Prevent, Cent Publ Hlth Lab, Vari, Greece

[7] St Georges Univ London, Inst Infect & Immun, London, England

[8] KAT Gen Hosp, Athens, Greece

[9] Thriassio Gen Hosp, Athens, Greece

[10] Sotiria Gen Hosp, Athens, Greece

[11] Ippokratio Gen Hosp, Athens, Greece

[12] Evagelismos Gen Hosp, Athens, Greece

[13] Attikon Gen Hosp, Athens, Greece

[14] Gen Univ Hosp, Larisa, Greece

[15] Paidon Pentelis Childrens Hosp, Athens, Greece

[16] Agia Olga Gen Hosp, Athens, Greece

[17] Univ Hosp, Patras, Greece

[18] Alfa Inst Biomed Sci, Athens, Greece

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2019年 / 53卷 / 06期

关键词：

Colistin; Azidothymidine; Synergism; Repurposing; Enterobacteriaceae; Gram-negative; GRAM-NEGATIVE BACTERIA; PSEUDOMONAS-AERUGINOSA; ANTIBACTERIAL ACTIVITY; ZIDOVUDINE; COMBINATION; PHARMACOKINETICS; 3-AZIDO-3-DEOXYTHYMIDINE; TIGECYCLINE; SALMONELLA; INFECTIONS;

D O I：

10.1016/j.ijantimicag.2019.02.021

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background: New antibiotics are urgently needed to treat multi-drug resistant infections; however, production of novel antibiotics is diminishing. Synergistic combination drug therapy to enhance the activity of available antibiotics may improve management of patients with resistant infections. Methods: Colistin-resistant Klebsiella pneumoniae isolates were collected from inpatients in 10 Greek hospitals and used to study combination activity of colistin plus azidothymidine. Combination activity was evaluated with the sum of fractional inhibitory concentrations (Sigma FIC) using the mini checkerboard broth microdilution method. Results: A hundred individual strains were tested. Synergistic activity was noted in 79% (79/100) of isolates and additive activity in the remaining 21% (21/100). Sigma FIC50 and Sigma FIC90 were 0.28 and 0.56, respectively. Conclusion: Colistin with azidothymidine exhibited promising synergistic activity against colistin-resistant Klebsiella pneumoniae isolates warranting further investigation of the combination. (C) 2019 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

引用

页码：855 / 858

页数：4

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