Synergistic activity of colistin with azidothymidine against colistin-resistant Klebsiella pneumoniae clinical isolates collected from inpatients in Greek hospitals

被引：16

作者：

Falagas, Matthew E. ^{[1
,2
,3
]}

Voulgaris, Georgios L. ^{[1
,4
]}

Tryfinopoulou, Kyriaki ^{[5
,6
]}

Giakkoupi, Panagiota ^{[5
,6
]}

Kyriakidou, Margarita ^{[1
]}

Vatopoulos, Alkiviadis ^{[5
,6
]}

Coates, Anthony ^{[7
]}

Hu, Yanmin ^{[7
]}

Tsiplakou, S. ^{[8
]}

Papaioannou, V ^{[8
]}

Trikka-Graphakos, E. ^{[9
]}

Charalampakis, N. ^{[9
]}

Sereti, C. ^{[9
]}

Vogiatzakis, E. ^{[10
]}

Moraiti, H. ^{[10
]}

Xanthaki, A. ^{[11
]}

Toutouza, M. ^{[11
]}

Fountoulis, K. ^{[12
]}

Perivolioti, E. ^{[12
]}

Kraniotaki, H. ^{[12
]}

Bournia, M. ^{[12
]}

Vourli, S. ^{[13
]}

Peteinaki, E. ^{[14
]}

Makri, A. ^{[15
]}

Daskalaki, M. ^{[15
]}

Staikou, E. ^{[15
]}

Platsouka, E. ^{[16
]}

Spiliopoulou, I ^{[17
]}

Christofidou, M. ^{[17
]}

Tryfinopoulou, K. ^{[5
,6
]}

Giakkoupi, P. ^{[5
,6
]}

Vatopoulos, A. ^{[5
,6
]}

Vardakas, K. ^{[18
]}

Voulgaris, G. ^{[18
]}

Kyriakidou, M. ^{[18
]}

Falagas, M. ^{[18
]}

机构：

[1] Alfa Inst Biomed Sci, 9 Neapoleos St, Athens 15123, Greece

[2] Henry Dunant Hosp Ctr, Dept Med, Athens, Greece

[3] Tufts Univ, Sch Med, Dept Med, Boston, MA 02111 USA

[4] 401 Gen Mil Hosp, Dept Pharm, Lab Pharmacokinet & Toxicol, Athens, Greece

[5] Natl Sch Publ Hlth, Dept Microbiol, Vari, Greece

[6] Hellen Ctr Dis Control & Prevent, Cent Publ Hlth Lab, Vari, Greece

[7] St Georges Univ London, Inst Infect & Immun, London, England

[8] KAT Gen Hosp, Athens, Greece

[9] Thriassio Gen Hosp, Athens, Greece

[10] Sotiria Gen Hosp, Athens, Greece

[11] Ippokratio Gen Hosp, Athens, Greece

[12] Evagelismos Gen Hosp, Athens, Greece

[13] Attikon Gen Hosp, Athens, Greece

[14] Gen Univ Hosp, Larisa, Greece

[15] Paidon Pentelis Childrens Hosp, Athens, Greece

[16] Agia Olga Gen Hosp, Athens, Greece

[17] Univ Hosp, Patras, Greece

[18] Alfa Inst Biomed Sci, Athens, Greece

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2019年 / 53卷 / 06期

关键词：

Colistin; Azidothymidine; Synergism; Repurposing; Enterobacteriaceae; Gram-negative; GRAM-NEGATIVE BACTERIA; PSEUDOMONAS-AERUGINOSA; ANTIBACTERIAL ACTIVITY; ZIDOVUDINE; COMBINATION; PHARMACOKINETICS; 3-AZIDO-3-DEOXYTHYMIDINE; TIGECYCLINE; SALMONELLA; INFECTIONS;

D O I：

10.1016/j.ijantimicag.2019.02.021

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background: New antibiotics are urgently needed to treat multi-drug resistant infections; however, production of novel antibiotics is diminishing. Synergistic combination drug therapy to enhance the activity of available antibiotics may improve management of patients with resistant infections. Methods: Colistin-resistant Klebsiella pneumoniae isolates were collected from inpatients in 10 Greek hospitals and used to study combination activity of colistin plus azidothymidine. Combination activity was evaluated with the sum of fractional inhibitory concentrations (Sigma FIC) using the mini checkerboard broth microdilution method. Results: A hundred individual strains were tested. Synergistic activity was noted in 79% (79/100) of isolates and additive activity in the remaining 21% (21/100). Sigma FIC50 and Sigma FIC90 were 0.28 and 0.56, respectively. Conclusion: Colistin with azidothymidine exhibited promising synergistic activity against colistin-resistant Klebsiella pneumoniae isolates warranting further investigation of the combination. (C) 2019 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

引用

页码：855 / 858

页数：4

共 50 条

[1] Combination of Colistin and Azidothymidine Demonstrates Synergistic Activity against Colistin-Resistant, Carbapenem-Resistant Klebsiella pneumoniae
Chang, Ya-Ting
Yang, Tsung-Ying
Lu, Po-Liang
Lin, Shang-Yi
Wang, Liang-Chun
Wang, Sheng-Fan
Hsieh, Ya-Ju
Tseng, Sung-Pin
MICROORGANISMS, 2020, 8 (12) : 1 - 12
[2] Synergistic Activity of Niclosamide in Combination With Colistin Against Colistin-Susceptible and Colistin-Resistant Acinetobacter baumannii and Klebsiella pneumoniae
Ayerbe-Algaba, Rafael
Luisa Gil-Marques, Maria
Enrique Jimenez-Mejias, Manuel
Sanchez-Encinales, Viviana
Parra-Millan, Raquel
Eugenia Pachon-Ibanez, Maria
Pachon, Jeronimo
Smani, Younes
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2018, 8
[3] Synergistic Activity of Colistin plus Rifampin against Colistin-Resistant KPC-Producing Klebsiella pneumoniae
Tascini, Carlo
Tagliaferri, Enrico
Giani, Tommaso
Leonildi, Alessandro
Flammini, Sarah
Casini, Beatrice
Lewis, Russell
Ferranti, Simone
Rossolini, Gian Maria
Menichetti, Francesco
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2013, 57 (08) : 3990 - 3993
[4] SYNERGISTIC ANTIBIOTIC COMBINATIONS FOR COLISTIN-RESISTANT KLEBSIELLA PNEUMONIAE
Kadar, Bela
Kocsis, Bela
Toth, Akos
Damjanova, Ivelina
Szasz, Mate
Kristof, Katalin
Nagy, Karoly
Szabo, Dora
ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA, 2013, 60 (02) : 201 - 209
[5] Quercetin Rejuvenates Sensitization of Colistin-Resistant Escherichia coli and Klebsiella Pneumoniae Clinical Isolates to Colistin
Lin, Yishuai
Zhang, Ying
Liu, Shixing
Ye, Dandan
Chen, Liqiong
Huang, Na
Zeng, Weiliang
Liao, Wenli
Zhan, Yizhou
Zhou, Tieli
Cao, Jianming
FRONTIERS IN CHEMISTRY, 2021, 9
[6] Resistome of carbapenem-and colistin-resistant Klebsiella pneumoniae clinical isolates
Lomonaco, Sara
Crawford, Matthew A.
Lascols, Christine
Timme, Ruth E.
Anderson, Kevin
Hodge, David R.
Fisher, Debra J.
Pillai, Segaran P.
Morse, Stephen A.
Khan, Erum
Hughes, Molly A.
Allard, Marc W.
Sharma, Shashi K.
PLOS ONE, 2018, 13 (06):
[7] First report of colistin-resistant Klebsiella pneumoniae clinical isolates in Lebanon
Okdah, Liliane
Leangapichart, Thongpan
Hadjadj, Linda
Olaitan, Abiola Olumuyiwa
Al-Bayssari, Charbel
Rizk, Rabih
Hammoud, Mahmoud
Diene, Seydina M.
Rolain, Jean-Marc
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, 2017, 9 : 15 - 16
[8] Ceragenin Csa-131 Retains Activity Against Colistin-Resistant Clinical Isolates Of Klebsiella Pneumoniae
Savage, P. B.
Hashemi, M. M.
Hilton, B.
Weber, S.
Genberg, C.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2017, 195
[9] The Combination of Doripenem and Colistin Is Bactericidal and Synergistic against Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae
Jernigan, Meredith G.
Press, Ellen G.
Nguyen, M. Hong
Clancy, Cornelius J.
Shields, Ryan K.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2012, 56 (06) : 3395 - 3398
[10] In Vitro Synergy of Colistin Combinations against Colistin-Resistant Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae Isolates
Vidaillac, Celine
Benichou, Lothaire
Duval, Raphael E.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2012, 56 (09) : 4856 - 4861

← 1 2 3 4 5 →