The miR-24-3p/p130Cas: a novel axis regulating the migration and invasion of cancer cells

被引：30
|
作者：
Kang, Hoin [1 ]
Rho, Jun Gi [2 ]
Kim, Chongtae [1 ]
Tak, Hyosun [1 ]
Lee, Heejin [1 ]
Ji, Eunbyul [1 ]
Ahn, Sojin [1 ]
Shin, A-Ri [3 ]
Cho, Hyun-Il
Huh, Yun Hyun [4 ]
Song, Woo Keun [2 ,4 ]
Kim, Wook [2 ]
Lee, Eun Kyung [1 ,5 ]
机构：
[1] Catholic Univ Korea, Coll Med, Dept Biochem, Seoul, South Korea
[2] Ajou Univ, Dept Mol Sci & Technol, Suwon, South Korea
[3] Catholic Univ Korea, Coll Med, Catholic Canc Res Inst, Seoul, South Korea
[4] Gwangju Inst Sci & Technol, Bio Imaging & Cell Dynam Res Ctr, Dept Life Sci, Gwangju, South Korea
[5] Catholic Univ Korea, Canc Evolut Res Ctr, Seoul, South Korea
来源：
SCIENTIFIC REPORTS | 2017年 / 7卷
基金：
新加坡国家研究基金会;
关键词：
DOWN-REGULATION; P130CAS; PROLIFERATION; EXPRESSION; RESISTANCE; MICRORNAS; MECHANISM; CARCINOMA; APOPTOSIS; PROTEIN;
D O I：
10.1038/srep44847
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression by suppressing translation or facilitating mRNA decay. Differential expression of miRNAs is involved in the pathogenesis of several diseases including cancer. Here, we investigated the role of-miR-24-3p as a downregulated miRNA in metastatic cancer. miR-24-3p was decreased in metastatic cancer and lower expression of miR-24-3p was related to poor survival of cancer patients. Consistently, ectopic expression of miR-24-3p suppressed the cell migration, invasion, and proliferation of MCF7, Hep3B, B16F10, SK-Hep1, and PC-3 cells by directly targeting p130Cas. Stable expression of p130Cas restored miR-24-3p-mediated inhibition of cell migration and invasion. These results suggest that miR-24-3p functions as a tumor suppressor and the miR-24-3p/p130Cas axis is a novel factor of cancer progression by regulating cell migration and invasion.
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页数：10
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