Thioglycuronides:: Synthesis and application in the assembly of acidic oligosaccharides

被引：137
|
作者：
van den Bos, LJ [1 ]
Codée, JDC [1 ]
van der Toorn, JC [1 ]
Boltje, TJ [1 ]
van Boom, JH [1 ]
Overkleeft, HS [1 ]
van der Marel, GA [1 ]
机构：
[1] Leiden Univ, Leiden Inst Chem, NL-2300 RA Leiden, Netherlands
来源：
ORGANIC LETTERS | 2004年 / 6卷 / 13期
关键词：
D O I：
10.1021/ol049380+
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Partially protected thioglycuronic acids are prepared efficiently by chemo- and regioselective oxidation of the corresponding thioglycosides using the TEMPO/BAIB reagent combination. After esterification, the thioglycuronic acids proved to be useful as both donor and acceptor in sulfonium-mediated condensations toward acidic di- and trisaccharides.
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页码：2165 / 2168
页数：4
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