New stereoselective preparation of (Z)-3-perfluoroalkyl-3-magnesiated enoates by an iodine-magnesium exchange

被引：10

作者：

Thibonnet, J

Duchêne, A

Parrain, JL

Abarbri, M

机构：

[1] Fac Sci Tours, Lab Physicochim Interfaces & Milieux React, F-37200 Tours, France

[2] Fac Sci & Tech St Jerome, CNRS, Organ Synth Lab, F-13397 Marseille 20, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 69卷 / 12期

关键词：

D O I：

10.1021/jo049960k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(Z)-Ethyl-3-perfluoroalkyl-3-magnesiated crotonates were prepared from (Z)-ethyl-3-perfluoroalkyl-3-iodo enoates by iodine-magnesium exchange reaction with isopropylmagnesium bromide in THF at -78 degreesC. These new reagents reacted with a range of electrophiles, leading to polyfunctional products bearing a perfluoroalkyl group.

引用

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页码：4262 / 4264

页数：3

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