Whole genome sequencing to decipher the virulence phenotype of hypervirulent Klebsiella pneumoniae responsible for liver abscess, Marseille, France

被引：6
|
作者：
Baron, Sophie Alexandra [1 ,2 ]
Pascale, Lea-Marie [1 ,2 ]
Million, Matthieu [1 ,2 ]
Briantais, Antoine [3 ]
Durand, Jean-Marc [3 ]
Hadjadj, Linda [1 ,2 ]
Rolain, Jean-Marc [1 ,2 ,4 ]
机构：
[1] Aix Marseille Univ, Fac Med & Pharm, MEPHI, APHM,IRD, 19-21 Blvd Jean Moulin, F-13385 Marseille 05, France
[2] IHU Mediterranee Infect, 19-21 Blvd Jean Moulin, F-13385 Marseille, France
[3] Hop La Timone, AP HM, Serv Med Interne, Marseille, France
[4] Aix Marseille Univ, Fac Med & Pharm, APHM, IRD,MEPHI,IHU Mediterranee Infect, 19-21 Blvd Jean Moulin, F-13385 Marseille 05, France
来源：
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2021年 / 40卷 / 05期
关键词：
Liver abscess; Klebsiella pneumoniae; Hypervirulent; ST86; ST23; STRAIN;
D O I：
10.1007/s10096-020-04080-7
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
We described three clinical cases of pyogenic liver abscess caused by hypervirulent Klebsiella pneumoniae (hvKp) successfully treated by prolonged antibiotherapy, in which one case was complicated by endophthalmitis. Whole genome sequencing helped to confirm the diagnosis of these hvKp strains, which belong to clonal complexes CC86 and CC23 and carried hvKp-associated genes (magA and/or rmpA). This syndrome is increasingly reported in France and Europe and raises questions about the source of infection.
引用
收藏
页码：1073 / 1077
页数：5
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