No association of vitamin D-binding protein gene polymorphisms in Japanese patients with MS

被引：41
|
作者：
Niino, M
Kikuchi, S
Fukazawa, T
Yabe, I
Tashiro, K
机构：
[1] Hokkaido Univ, Grad Sch Med, Dept Neurol, Kita Ku, Sapporo, Hokkaido 0608638, Japan
[2] Hokuyukai Neurol Hosp, Sapporo, Hokkaido, Japan
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2002年 / 127卷 / 1-2期
关键词：
multiple sclerosis; polymorphism; vitamin D-binding protein; Japanese;
D O I：
10.1016/S0165-5728(02)00099-1
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Vitamin D-binding protein (DBP) is known to function as an immunomodulatory factor, as well as the main carrier of vitamin D. We analyzed the frequencies of two polymorphisms (codon 416 and codon 420) in the DBP gene through a case-control study involving 107 Japanese patients with multiple sclerosis (MS) and 109 healthy controls. None of these polymorphisms showed any association with the occurrence of MS. Furthermore, no association was observed between the DBP polymorphisms and the age at disease onset. These results suggest that DBP does not contribute to the development of MS in Japanese. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：177 / 179
页数：3
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