Synthesis, Stability, and Antimicrobial Activity of Diiodobromides of 1H,2H,3H,4H-Pyrido-[4,3-d]Pyrimidinium Derivatives

被引：0

作者：

Kirsanova, Yu. A. ^{[1
]}

Chernov'yants, M. S. ^{[1
]}

Burykin, I. V. ^{[1
]}

Podoinitsyna, O. A. ^{[2
]}

机构：

[1] Southern Fed Univ, Fac Chem, Rostov Na Donu 344090, Russia

[2] Rostov On Don Sci Res Plague Inst, Rostov Na Donu 344002, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2015年 / 49卷 / 07期

关键词：

bromides and diiodobromides of 1H,2H,3H,4H-pyrido[4,3-d]pyrimidinium derivatives; stability of iodohalogenides; antimicrobial activity; IODINE;

D O I：

10.1007/s11094-015-1303-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Iodination of chloroform solutions of the bromides of 1H,2H,3H,4H-pyrido[4,3-d]pyrimidinium with a threefold excess of iodine was performed to synthesize the diiodobromides of the corresponding organic cations. The composition and structure of these compounds were confirmed by UV and H-1 NMR spectroscopic and potentiometric titration methods. Values for the stability constant lg beta (3.05 - 4.68) allowed active iodine concentrations at the bactericidal level to be produced in solutions of 1H,2H,3H,4H-pyrido[4,3-d]pyrimidinium diiodobromides. The minimum inhibitory concentrations (MIC) of 1H,2H,3H,4H-pyrido[4,3-d]pyrimidinium diiodobromides against E. coli were 1.0 +/- 0.25 mg/ml.

引用

页码：455 / 458

页数：4

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