Inherent influence of substituents of actinocyne amides on the mode of their binding to DNA

被引：0
|
作者：
Moroshkina, EB
Krivtsova, MA
Glibin, EN
机构：
[1] St Petersburg State Univ, St Petersburg 198904, Russia
[2] St Petersburg Tech Univ, St Petersburg 198013, Russia
[3] Mil Construct Engn Univ, St Petersburg 191185, Russia
来源：
BIOFIZIKA | 2002年 / 47卷 / 03期
关键词：
substituents of actinocin amides; DNA; mode of binding;
D O I：
暂无
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
The results of studies on the structure of complexes of DNA with compounds based on the actinocin chromophore, a center of binding of the antitumor antibiotic actinomicyn D to DNA, were analyzed. In positions 1 and 9 of the chromophore of these compounds, pentapeptide lact ones of actinomicyn D are replaced by groups of various origin. By using spectral, optical, and hydrodynamic methods a model of binding to DNA for each compound was constructed, and some regularities of complex formation depending on the structure of actinocin substituents and the amount of ligands in the complex were revealed.
引用
收藏
页码：444 / 448
页数：5
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