Studies towards the synthesis of trocheliophorolides

被引：5
|
作者：
Khomane, Navnath B. [1 ,2 ]
Meshram, Harshadas M. [3 ,4 ]
Rode, Haridas B. [1 ,2 ]
机构：
[1] Indian Inst Chem Technol, CSIR, Dept Organ Synth & Proc Chem, Hyderabad 500007, Telangana, India
[2] Acad Sci & Innovat Res, New Delhi 110025, India
[3] Indian Inst Chem Technol, CSIR, Med Chem & Biotechnol Div, Hyderabad 500007, Telangana, India
[4] Meshram Life Sci Pvt Ltd, Hyderabad 500007, Telangana, India
来源：
TETRAHEDRON LETTERS | 2018年 / 59卷 / 22期
关键词：
Trocheliophorolides; Butenolides; Eglinton oxidative dimerization; Cadiot-Chodkiewicz cross coupling; Cross metathesis; CROSS-METATHESIS; NATURAL-PRODUCTS; FORMAL SYNTHESIS; BUTENOLIDES; ENANTIOMER; EFFICIENT; CIS;
D O I：
10.1016/j.tetlet.2018.04.045
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Total synthesis of trocheliophorolide C epimer is reported. The synthetic strategy involves generation of lactone skeleton and preparation of unsaturated side chain followed by cross-metathesis. The Eglinton oxidative coupling, Cadiot-Chodkiewicz cross-coupling and cross-metathesis are the key reactions used in the synthesis. We also attempted the synthesis of trocheliophorolide D epimer, which includes Cu catalyzed various cross-coupling reactions. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2157 / 2160
页数：4
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