Use of Mesenchymal Stem Cells for Possible Repair of Doxorubicin-Damaged Organs and Tissues in Experimental Monkeys

被引：3
|
作者：
Agrba, V. Z. [1 ]
Karal-Ogly, D. D. [1 ]
Gvozdik, T. E. [1 ]
Kaplanyan, P. A. [1 ]
Demenkova, N. P. [1 ]
Gvaramiya, I. A. [1 ]
Mukhametzyanova, E. I. [1 ]
Shamsutdinova, O. A. [1 ]
Chuguev, Yu. P. [1 ]
Kal'sina, S. Sh. [1 ]
Konoplyannikov, A. G. [1 ]
Araviashvili, D. E. [1 ]
Klots, I. N. [1 ]
Lapin, B. A. [1 ]
机构：
[1] Res Inst Med Primatol, Soci, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2018年 / 165卷 / 01期
关键词：
stem cells; doxorubicin; monkeys; B lymphocytes; cytokines; CELLULAR-IMMUNITY; PRIMATES;
D O I：
10.1007/s10517-018-4108-8
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Three injections of doxorubicin to rhesus macaques cause severe intoxication, characterized by anemia, cachexia, and degeneration of the viscera. The life span of monkeys injected with the drug and receiving after 24 h mesenchymal stem cell transplantation varied from 96 to 120 days in comparison with 50-74 days in animals receiving stem cells before doxorubicin. Controls received doxorubicin and saline; the lifespan of one monkey was 24 days, of the other - 1 year and 8 months. The increase in activity of proinflammatory cytokine IL-6 was paralleled by an increase in the level of C-reactive protein.
引用
收藏
页码：101 / 104
页数：4
相关论文
共 50 条
  • [21] The use of bone marrow mesenchymal stem cells to repair the infarcted heart
    Tomita, S
    Parbhakar, RKLS
    Al-Radi, O
    Weisel, RD
    Mickle, DAG
    CARDIAC REMODELING AND FAILURE, 2003, 5 : 345 - 354
  • [22] Use of mesenchymal stem cells for cutaneous repair and skin substitute elaboration
    Laverdet, B.
    Micallef, L.
    Lebreton, C.
    Mollard, J.
    Lataillade, J. -J.
    Coulomb, B.
    Desmouliere, A.
    PATHOLOGIE BIOLOGIE, 2014, 62 (02): : 108 - 117
  • [23] Use of mesenchymal stem cells seeded on the scaffold in articular cartilage repair
    Kaoru Yamagata
    Shingo Nakayamada
    Yoshiya Tanaka
    Inflammation and Regeneration, 38
  • [24] Chemokines in mesenchymal stem cell therapy for bone repair: a novel concept of recruiting mesenchymal stem cells and the possible cell sources
    Ito, Hiromu
    MODERN RHEUMATOLOGY, 2011, 21 (02) : 113 - 121
  • [25] In Vivo Differentiation of Magnetically Labeled Mesenchymal Stem Cells Into Hepatocytes for Cell Therapy to Repair Damaged Liver
    Ju, Shenghong
    Teng, Gao-Jun
    Lu, Haihua
    Jin, JiYang
    Zhang, Yu
    Zhang, Aifeng
    Ni, Yicheng
    INVESTIGATIVE RADIOLOGY, 2010, 45 (10) : 625 - 633
  • [26] The use of laryngeal mucosa mesenchymal stem cells for the repair the vocal fold injury
    Peng, Han
    Ming, Leiguo
    Yang, Runqin
    Liu, Yang
    Liang, Yuanyuan
    Zhao, Yu
    Jin, Yan
    Deng, Zhihong
    BIOMATERIALS, 2013, 34 (36) : 9026 - 9035
  • [27] Pressure Ulcers: Description of a New Model and Use of Mesenchymal Stem Cells for Repair
    de la Garza-Rodea, Anabel S.
    Knaan-Shanzer, Shoshan
    van Bekkum, Dirk W.
    DERMATOLOGY, 2011, 223 (03) : 266 - 284
  • [28] Current clinical evidence for the use of mesenchymal stem cells in articular cartilage repair
    Reissis, Dimitris
    Quen Oak Tang
    Cooper, Nina Catherine
    Carasco, Clare Francesca
    Gamie, Zakareya
    Mantalaris, Athanasios
    Tsiridis, Eleftherios
    EXPERT OPINION ON BIOLOGICAL THERAPY, 2016, 16 (04) : 535 - 557
  • [29] HORSE SPECIES SYMPOSIUM: Use of mesenchymal stem cells in fracture repair in horses
    Govoni, K. E.
    JOURNAL OF ANIMAL SCIENCE, 2015, 93 (03) : 871 - 878
  • [30] Natural small molecules synergize mesenchymal stem cells for injury repair in vital organs: a comprehensive review
    Qu, Yanling
    Wang, Zhe
    Dong, Lingjuan
    Zhang, Dan
    Shang, Fengqing
    Li, Afeng
    Gao, Yanni
    Bai, Qinhua
    Liu, Dan
    Xie, Xiaodong
    Ming, Leiguo
    STEM CELL RESEARCH & THERAPY, 2024, 15 (01)
12345