Triterpenoid saponins from the rhizomes of Anemone flaccida and their inhibitory activities on LPS-induced NO production in macrophage RAW264.7 cells

被引：21
|
作者：
Huang, Xiao-Jun [1 ,2 ]
Tang, Jing-Qun [1 ,2 ]
Li, Man-Mei [1 ]
Liu, Qing [1 ]
Li, Yao-Lan [1 ]
Fan, Chun-Lin [1 ]
Pei, Hong [3 ]
Zhao, Hui-Nan [1 ]
Wang, Ying [1 ,2 ]
Ye, Wen-Cai [1 ,2 ]
机构：
[1] Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China
[2] Jinan Univ, Coll Pharm, JNU HKUST Joint Lab Neurosci & Innovat Drug Res, Guangzhou 510632, Guangdong, Peoples R China
[3] GKH Pharmaceut Ltd, Guangzhou 511440, Guangdong, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2014年 / 16卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Anemone flaccida; Ranunculaceae; triterpenoid saponin; anti-inflammatory; RAW264.7; cells; OLEANANE SAPONINS; CONSTITUENTS; GLYCOSIDES; PATHWAY; LEAVES; ROOTS;
D O I：
10.1080/10286020.2014.954554
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A new ursane-type triterpenoid saponin, flaccidoside IV (1), and three new oleanane-type triterpenoid saponins, flaccidosides V-VII (2-4), along with 17 known saponins (5-21), were isolated from the rhizomes of Anemone flaccida. The structures of the new triterpenoid saponins were determined based on spectroscopic analyses and chemical methods. All the isolated saponins were tested for their inhibitory activities on lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages, and several bisdesmosidic oleanane-type triterpenoid saponins (2, 7, and 10) showed significant inhibitory activities, which indicated they had potential anti-inflammatory activities under their noncytotoxic concentrations in vitro.
引用
收藏
页码：910 / 921
页数：12
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