28-Nor-oleanane-type triterpene saponins from Camellia japonica and their inhibitory activity on LPS-induced NO production in macrophage RAW264.7 cells

被引：21

作者：

Thao, Nguyen Thi Phuong ^{[1
]}

Hung, Tran Manh ^{[1
]}

Cuong, To Dao ^{[1
]}

Kim, Jin Cheol ^{[2
]}

Kim, Eun Hee ^{[3
]}

Jin, Seong Eun ^{[4
]}

Na, MinKyun ^{[5
]}

Lee, Young Mi ^{[6
]}

Kim, Young Ho ^{[7
]}

Choi, Jae Sue ^{[4
]}

Min, Byung Sun ^{[1
]}

机构：

[1] Catholic Univ Daegu, Coll Pharm, Gyongsan 712702, South Korea

[2] Korea Res Inst Chem Technol, Taejon 305600, South Korea

[3] Korea Basic Sci Inst, Div Magnet Resonance, Chungbuk 363883, South Korea

[4] Pukyong Natl Univ, Pusan 608737, South Korea

[5] Yeungnam Univ, Coll Pharm, Gyeongbuk 712749, South Korea

[6] Wonkwang Univ, Coll Pharm, Jeonbuk 570749, South Korea

[7] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 24期

关键词：

Camellia japonica; Theaceae; 28-Nor-oleanolic acid; NO inhibition; THEACEOUS PLANTS; COMPLEX TANNINS; OLIGOGLYCOSIDES; ABSORPTION; FLOWERS; SEEDS;

D O I：

10.1016/j.bmcl.2010.10.013

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new 28-nor-oleanane-type triterpene oligoglycosides, camellenodiol 3-O-beta-D-galactopyranosyl (1 -> 2)[beta-D-xylopyranosyl(1 -> 2)-beta-D-galactopyranosyl(1 -> 3)]-beta-D-glucuronopyranoside (2), camellenodiol 3-O-4 ''-O-acetyl-beta-D-galactopyranosyl(1 -> 2)[beta-D-xylopyranosyl(1 -> 2)-beta-D-galactopyranosyl(1 -> 3)] beta-D-glucuronopyranoside (4), camellenodiol 3-O-(beta-D-galactopyranosyl(1? 2)[ b-D-xylopyranosyl(1 -> 2)beta-D-galactopyranosyl(1 -> 3)]-6 '-methoxy-beta-D-glucuronopyranoside (5), and maragenin II 3-O-(b-D-galactopyranosyl(1 -> 2)[ b-D-xylopyranosyl(1 -> 2)-b-D-galactopyranosyl(1 -> 3)]-6 '-methoxy-beta-D-glucuronopyranoside (6), along with two known compounds, (1 and 3), were isolated from the stem bark of Camellia japonica. Their chemical structures were established mainly by 2D NMR techniques and mass spectrometry. The isolated compounds showed inhibitory effects on NO production in RAW264.7 macrophages. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：7435 / 7439

页数：5

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