Synthesis of glycose carbamides and evaluation of the induction of erythroid differentiation of human erythroleukemic K562 cells

被引：5

作者：

Landi, Martina ^{[1
]}

Catelani, Giorgio ^{[1
]}

D'Andrea, Felicia ^{[1
]}

Ghidini, Eleonora ^{[2
]}

Amari, Gabriele ^{[2
]}

Paola, Puccini ^{[2
]}

Bianchi, Nicoletta ^{[3
]}

Gambari, Roberto ^{[3
]}

机构：

[1] Univ Pisa, Dipartimento Chim Bioorgan & Biofarm, I-56126 Pisa, Italy

[2] Chiesi Farmaceut SpA, I-43100 Parma, Italy

[3] Univ Ferrara, Dipartimento Biochim & Biol Mol, I-44100 Ferrara, Italy

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 02期

关键词：

Carbamides; Monosaccharides; Erythroid differentiation; K562; cells; FETAL-HEMOGLOBIN PRODUCTION; GLOBIN MESSENGER-RNA; BETA-THALASSEMIA; GENE-EXPRESSION; PRECURSOR CELLS; ACCUMULATION; DERIVATIVES; INDUCERS; MONOSACCHARIDES; MITHRAMYCIN;

D O I：

10.1016/j.ejmech.2008.05.001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of carbamides derived from 1,2:5,6-di-O-isopropylidene-D-gluco- (1) and D-allofuranose (3) as well as their 5,6-O-deprotected analogues (2 and 4) and methyl 3,4-O-isopropylidene-alpha- and beta-D-galactopyranosides (5 and 6) have been prepared in order to evaluate their ability to induce erythroid differentiation of human erythroleukemic K562 cells. Twenty out of 51 carbamides tested exhibit an appreciable activity as inducers of erythroid differentiation and have been fully characterized and described. (c) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：745 / 754

页数：10

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